摘要
多发性骨髓瘤(MM)是一种多见于老年人的骨髓浆细胞异常增殖的血液系统恶性肿瘤,起病隐匿。目前诊断方式主要依赖M蛋白的检测和有创性骨髓穿刺活组织检查,常规影像学检查的灵敏度和特异性较低,分子影像技术为MM的无创性诊断提供了新的选择和方法。全身MRI具有很好的软组织对比度和空间分辨率,可以显示骨髓浸润和血管情况;^(18)F-FDG、乙酸盐、胆碱、蛋氨酸等代谢显像具有较高灵敏度;免疫PET显像则为患者筛选特异性靶标进行靶向或免疫治疗,并在治疗后进行有效的疗效评估。该文对MM的分子影像学,尤其是免疫PET显像的研究进展进行综述。
Multiple myeloma(MM)is a malignant tumor of the blood system that is more common in the elderly with abnormal proliferation of bone marrow plasma cells.The current diagnostic methods mainly rely on the detection of M protein and invasive bone marrow aspiration biopsy.The sensitivity and specificity of conventional imaging tests are low.Molecular imaging technology provides new options and methods for the noninvasive diagnosis of MM.Whole-body MRI(WB-MRI)has good soft tissue contrast and spatial resolution,which can show bone marrow infiltration and vascular conditions.Metabolic imaging such as^(18)F-FDG,acetate,choline,and methionine are highly sensitive.ImmunoPET imaging screens specific targets for targeted therapy or immunotherapy and evaluates the efficacy.This article reviews the progress of molecular imaging in MM,especially immunoPET imaging.
作者
李翠翠
王荣福
康磊
Li Cuicui;Wang Rongfu;Kang Lei(Department of Nuclear Medicine,Peking University First Hospital,Beijing 100034,China)
出处
《中华核医学与分子影像杂志》
CAS
CSCD
北大核心
2022年第1期44-47,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
