摘要
目的观察维生素D辅助治疗感染性腹泻对患儿血清中25(OH)D_(3)及血清因子的影响。方法选取2018年6月至2020年6月于延安市中医医院儿科就诊的感染性腹泻患儿120例,按照随机数表法分为对照组和观察组,每组60例。对照组患儿给予常规治疗,观察组患儿在对照组治疗的基础上给予维生素D滴剂,两组患者均治疗72 h。比较两组患儿的临床疗效及不良反应,以及治疗前及治疗72 h后的白介素-6(IL-6)、白介素-7(IL-7)、白介素-23(IL-23)及肿瘤坏死因子-α(TNF-α)和25(OH)D_(3)水平。结果治疗后,观察组患儿的的临床总有效率为98.33%,明显高于对照组的78.33%,差异有统计学意义(P<0.05);观察组患儿治疗过程中的总不良反应发生率为6.67%,略低于对照组的11.67%,但差异无统计学意义(P>0.05);治疗前,两组患者的血清25(OH)D_(3)、IL-6、IL-7、IL-23及TNF-α水平比较差异均无统计学意义(P>0.05);治疗72 h后,两组患儿的血清25(OH)D_(3)水平明显升高,IL-6、IL-7、IL-23及TNF-α水平明显下降,且观察组患儿的血清25(OH)D_(3)明显高于对照组,IL-6、IL-7、IL-23及TNF-α水平明显低于对照组,差异均有统计学意义(P<0.05)。结论维生素D用于感染性腹泻的治疗具有良好的临床疗效,且可提高患儿血清中维生素D含量,减轻炎症反应,安全性高。
Objective To observe the effects of vitamin D adjuvant treatment of infectious diarrhea on serum25(OH)D_(3)and serum factors in children.Methods A total of 120 children with infectious diarrhea treated in the Department of Pediatrics at Yan’an Traditional Chinese Medicine Hospital from June 2018 to June 2020 were selected and divided into a control group and an observation group according to the random number table method,with 60 cases in each group.Children in the control group were given routine treatment,and children in the observation group received vitamin D drops on the basis of treatment in the control group.Both groups were treated for 72 hours.The clinical efficacy and adverse effects were compared between the two groups,as well as the levels of interleukin-6(IL-6),interleukin-7(IL-7),interleukin-23(IL-23),tumor necrosis factor-α(TNF-α),and 25(OH)D_(3)before treatment and 72 hours after treatment.Results After treatment,the total clinical efficiency of children in the observation group was 98.33%,which was significantly higher than 78.33%in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions during the treatment in the observation group was 6.67%,slightly lower than 11.67%in the control group(P>0.05).Before treatment,there was no significant difference in the levels of serum 25(OH)D_(3),IL-6,IL-7,IL-23,and TNF-α(P>0.05).After 72 hours of treatment,the serum 25(OH)D_(3)levels of the two groups increased significantly,the levels of IL-6,IL-7,IL-23,and TNF-αdecreased significantly;and the serum 25(OH)D_(3)was significantly higher in the observation group than in the control group,and the levels of IL-6,IL-7,IL-23,and TNF-αwere significantly lower than those of the control group(P<0.05).Conclusion Vitamin D has a good clinical effect in the treatment of infectious diarrhea.It can increase the content of vitamin D in the serum of children,reduce inflammatory response,and have high safety.
作者
胡玉玲
高永伟
王栋梅
马文玲
HU Yu-ling;GAO Yong-wei;WANG Dong-mei;MA Wen-ling(Department of Pediatrics,Yan'an Traditional Chinese Medicine Hospital,Yan'an 716000,Shaanxi,CHINA;Department of Pediatrics,Yan'an University Affiliated Hospital,Yan'an 716000,Shaanxi,CHINA;Department of Pediatrics,Yan'an People's Hospital,Yan'an 716000,Shaanxi,CHINA;Department of Pediatrics,Zhidan County People's Hospital,Yan'an 717500,Shaanxi,CHINA)
出处
《海南医学》
CAS
2022年第4期479-482,共4页
Hainan Medical Journal
