摘要
目的分析潍坊地区6岁以下儿童维生素D营养状态及相关危险因素,为防治维生素D缺乏或不足的相关疾病提供参考。方法选取2016年8月-2018年8月在诸城市妇幼保健院体检的5132例6岁以下体检儿童为研究对象,采用酶联免疫吸附法测定血清25-羟基维生素D[25-(OH)D]水平,分别从性别、年龄、季节等方面分析6岁以下儿童维生素D营养状态,并对其可能的危险因素进行单因素及logistic多元回归分析。结果6岁以下儿童维生素D缺乏率为10.76%,不足率为16.62%。6岁以下男女儿童血清25-(OH)D水平、维生素D缺乏率、不足率比较差异无统计学意义(均P>0.05)。6岁以下儿童3~6岁段维生素D缺乏率与不足率高于0~1岁段、1~2岁段、2~3岁段(均P<0.05),3~6岁段血清25-(OH)D水平低于0~1岁段、1~2岁段、2~3岁段(均P<0.05)。6岁以下儿童夏、秋季血清25-(OH)D水平高于春、冬季(均P<0.05),夏、秋季维生素D缺乏率与不足率显著低于春、冬季(均P<0.05)。影响6岁以下儿童维生素D缺乏或不足的危险因素为乱服或未服维生素D制剂、单独母乳喂养、户外运动<2 h/d、母亲文化程度低、反复上呼吸道感染、反复腹泻病、挑食或厌食及反复支气管哮喘。结论维生素D缺乏或不足率为27.38%,与年龄及季节有关,且维生素D缺乏或不足主要集中在3~6岁年龄段及春、冬两季,其个体影响因素主要有喂养方式、户外运动、挑食或厌食、维生素D制剂、母亲文化、反复上呼吸道感染、反复腹泻病及反复支气管哮喘。
Objective To analyze the Vitamin D levels and analysis of related risk factors in 5132 children under 6 years old in Weifang area,and to provide reference for prevention and treatment of diseases related to vitamin D deficiency or unsufficient.Methods A total of 5132 children under 6 years old examined in our hospital from August 2016 to August 2018 were selected as research subject.The serum 25-hydroxyvitamin D[25-(OH)D]levels of children were determined by enzyme-linked immunosorbent assay.The nutritional status of vitamin D in children were analyzed from the aspects of gender,age and season.The possible risk factors were analyzed by single factor and logistic multiple regression analysis.Results The vitamin D deficiency rate was 10.76%in children under 6 years old,and the unsufficient rate was 16.62%.The serum 25-(OH)D levels,vitamin D deficiency rate,and unsufficient rate were not significantly different between boys and girls under 6 years of age(all P>0.05).The vitamin D deficiency rate and unsufficient rate in children aged 3 to 6 years old is higher than 0-1 years old,1-2 years old,2-3 years old(all P<0.05),and the serum 25-(OH)D levels of 3-6 years old is was lower than 0-1 years old,1-2 years old,and 2-3 years old(all P<0.05).The vitamin D deficiency rate and unsufficient rate in summer and autumn were significantly lower than those in spring and winter(P<0.05).The risk factors affecting vitamin D deficiency or unsufficient in children under 6 years old were chaotic or not taking vitamin D preparation,breastfeeding alone,outdoor exercise<2 hours/day,low maternal education,repeated upper respiratory tract infection,Repeated diarrhea,picky or anorexia and repeated bronchial asthma.Conclusion The deficiency or unsufficient rate of vitamin D is 27.38%,which is related to age and season.The deficiency or unsufficient of vitamin D is mainly concentrated in the age of 3-6 years and spring and winter.The main influencing factors are feeding mode,outdoor sports,picky or anorexia,vitamin D preparation,mother cult
作者
张明
邱蕾
贺玉霜
董春萍
钟照刚
王明月
ZHANG Ming;QIU Lei;HE Yu-shuang;DONF Chun-ping;ZHONG Zhao-gang;WANG Ming-yue(Laboratory of Zhucheng Maternal and Child Health Hospital,Weifang,Shandong 262200,China;不详)
出处
《中华全科医学》
2020年第5期779-782,共4页
Chinese Journal of General Practice
基金
2017年山东省中医药科技发展计划项目(2017-110)
潍坊市卫生健康委科研项目(wfwsjk-2019-148)。
关键词
维生素D
营养状态
危险因素
儿童
Vitamin D
Nutritional status
Risk factors
Children
