摘要
目的分析在有效抗炎基础上定期补充乳杆菌活菌胶囊对哺乳期需氧菌性阴道炎患者的疗效及对远期复发率的影响。方法选择2019年4月至2020年3月于大连市妇女儿童医疗中心(集团)行产后42 d检查时发现的需氧菌性阴道炎患者共120例,按照随机自愿原则将所选患者分为观察组及对照组,各60例。全部患者均使用红核妇洁洗液及克林霉素磷酸酯阴道凝胶抗炎治疗7 d,观察组患者于第8天开始给予阴道用乳杆菌活菌胶囊每日睡前上药1粒,治疗10 d,停药后1周对两组患者进行临床疗效评估并了解不良反应发生情况。于首次治疗结束后第3个月及第6个月进行定期随诊,了解两组患者阴道炎的复发情况。且观察组患者于治疗后第3个月随诊结束后再次给予阴道用乳杆菌活菌胶囊补充上药1疗程。记录并比较两组患者治疗前、治疗后1周、治疗后第3个月及第6个月阴道pH值及H_(2)O_(2)情况。结果两组患者治疗期间均未发生明显不良反应。治疗后1周观察组患者治愈率(66.7%)显著高于对照组(36.7%),差异有统计学意义(P<0.05);观察组总有效率(95.0%)与对照组(86.7%)比较差异无统计学意义(P>0.05)。观察组治疗后第3个月复发率(5.0%)及第6个月复发率(11.7%)均明显低于同时段对照组(30.0%,56.7%),差异均有统计学意义(均P<0.05)。治疗后1周观察组患者阴道pH值正常率(95.0%)与对照组(86.7%)比较,差异无统计学意义(P>0.05),但观察组H_(2)O_(2)正常率(91.7%)明显高于对照组(63.3%),差异有统计学意义(P<0.05)。治疗后第3个月及第6个月观察组患者阴道pH值正常率(90.0%,85.0%)及H_(2)O_(2)正常率(86.7%,81.7%)均明显高于同时段对照组(53.3%、28.3%;45.0%、21.7%),差异均有统计学意义(均P<0.05)。结论在有效抗炎治疗基础上定期给予阴道用乳杆菌活菌胶囊补充治疗,能明显提高哺乳期需氧菌性阴道炎患者的治愈率,改善阴道pH值及H_(2)O_(2)情�
Objective To analyze the efficacy of regular supplementation of Viable Lactobacillus Capsule on basis of effective anti-inflammation in patients with aerobic vaginitis(AV)during lactation and the influence on the long-term recurrence rate.Methods A total of 120 patients with AV who were diagnosed about 42 days after delivery in our hospital from April 2019 to March 2020 were selected,and randomly divided into observation group or control group,with 60 patients in each group.All the patients were given Honghe Fujie vaginal lotion and clindamycin phosphate vaginal gel for 7 days.From day 8,the observation group was given vaginal Viable Lactobacillus Capsule before bedtime for 10 days.The efficacy and adverse reactions were recorded.Regular follow-up was conducted at 3 and 6 months after the end of the first treatment to observe the recurrence of vaginitis.After 3 months of treatment,the observation group was given Viable Lactobacillus Capsule again for 1 course of treatment.The vaginal pH and H_(2)O_(2)were recorded and compared between groups before and one week after treatment,and at 3 and 6 months after treatment.Results There were no serious adverse reactions in both groups.One week after treatment,the cure rate in the observation group(66.7%)was significantly higher than that in the control group(36.7%)(P<0.05).The total efficiency rate in the observation group had no significant difference with the control group(95.0%vs 86.7%,P>0.05).The recurrence rates at 3 months and 6 months after treatment in the observation group(5.0%,11.7%)were significantly lower than those in the control group(30.0%,56.7%)(all P<0.05).One week after treatment,there was no significant difference in the rates of normal vaginal pH between observation group(95.0%)and control group(86.7%)(P>0.05),but in the rate of normal H_(2)O_(2)(91.7%in observation group vs 63.3%in control group,P<0.05).Three months and 6 months after treatment,the rates of normal vaginal pH(90.0%,85.0%)and H_(2)O_(2)(86.7%,81.7%)in the observation group were signific
作者
谷丽娜
曲学玲
申英姬
GU Li-na;QU Xu-ling;SHEN Ying-ji(Dalian Maternal and Child′s Medical Center(Group),Dalian,Liaoning 116033,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2022年第1期86-90,共5页
Chinese Journal of Microecology
