摘要
气道炎症与气道重塑是支气管哮喘(哮喘)长期反复发作以及病死率逐渐升高的主要原因。近年来,随着对表观遗传学认识的深入,人们逐步发现了表观遗传学在哮喘发生发展中的重要作用。本文综述了DNA甲基化、组蛋白修饰和microRNA基因调控三大表观遗传学在哮喘发病机制中的作用。
Airway inflammation and airway remodeling are leading cause for long-term repeated attack of bronchial asthma and the gradual increasing fatality rate.In recent years,with the deepening understanding of epigenetics,epigenetics is considered as a major contributor of asthma pathogenesis.This article reviews the roles of the three epigenetics of DNA methylation,histone modification and MicroRNA role in the pathogenesis of asthma.
作者
李晓慧
霍如婕
田新瑞
Li Xiaohui;Huo Rujie;Tian Xinrui(Department of Respiratory and Critical Care Medicine,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《国际呼吸杂志》
2022年第3期233-236,共4页
International Journal of Respiration
基金
山西省重点研发计划(国际合作)(201903D421066)。
