摘要
目的 :评价白细胞介素 - 13(IL - 13)、总 Ig E (t Ig E)在急性支气管哮喘 (bronchial asthm a,BA )患儿发病的作用。方法 :采用免疫微粒子酶放大化学发光法分析 34例急性支气管哮喘患儿外周血 t Ig E,同时用酶联免疫吸附双抗体夹心法检测血浆 IL - 13水平的变化。结果 :小儿急性支气管哮喘 IL - 13水平为 (2 1.6 6± 9.32 )μg/L ,t Ig E为 (30 4.39± 88.75 )μg/L ,二者有显著相关 (r=0 .6 89,P <0 .0 0 1) ,与正常对照组比较均有显著性差异 (分别为 P <0 .0 1、 P <0 .0 0 1)。结论 :在小儿急性支气管哮喘时 ,机体过度表达 IL - 13和 t Ig E,检测 IL - 13、 t Ig E水平对观察小儿急性支气管哮喘治疗效果及病情的监测有积极的作用。
Objective:To evaluate the role of interleukin-13 and tIgE in acute bronchial asthma.Methods:Levels of tIgE 34 patients with acute bronchial asthma were measured using immunological microparticle enzyme-multiplied chemiluminescence technique and IL-3 were detected with an enzyme-linked immunosorbent assay.Results:Plasma concentrations of IL-13 and tIgE in children with bronchial asthma were (21.66±9.32)μg/L and (304.39±88.75)μg/L respectively.There was correlation between IL-13 and tIgE(r=0.689,P<0.001).Compared with healthy group levels of IL-13 and tIgE in patient group were significantly elevated(P<0.01 and P<0.001).Conclusion:There are high expressions of IL-13 and tIgE in children with bronchial asthma.Detection of IL-13 and tIgE play an important role in valuation of therapeutic effect and monitoring of the diseases.
出处
《广西医学》
CAS
2002年第10期1543-1544,共2页
Guangxi Medical Journal
