摘要
优选芩补中药牙周缓释凝胶制备的处方工艺并考察其药剂学性能。通过检测碱性磷酸酶(ALP)含量,获得黄芩提取物与骨碎补提取物配伍的最佳质量比,并通过形态学、pH值、流变学、稳定性、回收率及药物的体外释放率等指标,考察制备得到的芩补中药牙周缓释凝胶的制剂学情况。黄芩提取物与骨碎补提取物配伍的最佳质量比为1∶1,且4%的芩补中药缓释凝胶的制剂学指标最佳。制备最佳配比的芩补缓释凝胶,为进一步考察其对小型猪牙周炎模型的体内药效学奠定实验基础。
To optimize the formulation of Qinbu sustained-release gel and to study its pharmaceutical properties.By detecting the content of alkaline phosphatase(ALP),the optimum quality ratio of Scutellaria extract and bone fragment extract was obtained.Then the Qinbu sustained-release gel for periodontitis was investigated through the morphology,pH value,rheology,stability,recovery rate and drug release rate in vitro.The optimal mass ratio of Scutellaria extract and bone fragment extract was 1∶1.The pharmaceutical indexs of 4%Qinbu sustained-release gel were the best.The optimal ratio of Qinbu sustained-release gel was prepared,which laid an experimental foundation for further investigation of its pharmacodynamics in vivo for the treatment of periodontitis in mini pigs.
作者
刘瑾
仇冬冬
孙俊毅
杨冬梅
裴丹丹
苟建重
李昂
LIU Jin;QIU Dongdong;SUN Junyi;YANG Dongmei;PEI Dandan;GOU Jianzhong;LI Ang(Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,Xi′an 710004,China;Department of Periodontology,Medical College of Stomatology,Xi′an Jiaotong University,Xi′an 710004,China;Department of Special Clinic,Medical College of Stomatology,Xi′an Jiaotong University,Xi′an 710004,China;Department of Prosthodontics,Medical College of Stomatology,Xi′an Jiaotong University,Xi′an 710004,China)
出处
《西北大学学报（自然科学版）》
CAS
CSCD
北大核心
2022年第1期76-83,共8页
Journal of Northwest University（Natural Science Edition）
基金
国家自然科学基金资助项目(81704128)
陕西省社会发展基金资助项目(2021SF-049)。
关键词
黄芩
骨碎补
提取物
牙周缓释凝胶
药剂学
Scutellaria
bone fragment
extract
periodontal sustained-release gel
pharmacology
