摘要
目的研究急诊切痂植皮联合重组人碱性成纤维细胞生长因子(rh-bFGF)治疗中小面积深度烧伤的效果。方法选取142例中小面积深度烧伤患者为研究对象,根据治疗方式的不同,分为对照组(切痂植皮,71例)和联合组(切痂植皮+rhbFGF,71例),比较两组手术情况、术后皮片存活率、炎性反应、过敏反应及创面组织成纤维细胞(FB)、毛细血管计数。结果联合组平均手术面积(17.81±4.92)%与对照组的(17.39±4.86)%比较无统计学差异(P>0.05);联合组皮片存活率100%显著高于对照组的91.55%(P<0.05);联合组15d和20d时的愈合率明显高于对照组(P<0.05),平均愈合时间明显短于对照组(P<0.05);对照组炎性反应阳性率明显高于联合组(P<0.05),两组过敏反应阳性率比较无统计学差异(P>0.05);两组术后创面组FB和毛细血管数量呈上升趋势(P<0.05),联合组术后14d、21d创面组织FB和毛细血管数量明显多于对照组(P<0.05)。结论急诊切痂植皮联合rh-bFGF可减少中小面积深度烧伤患者创面炎性反应,促进FB增生和毛细血管新生,加快创面愈合。
Objective To study the effectS of emergency escharectomy and skin grafting combined with recombinant human basic fibroblast growth factor(rh-bFGF)on middle and small area deep burn wounds.Methods 142 cases of patients with middle and small area deep burn treated in our hospital were selected for the study and divided into the escharectomy and skin grafting group(n=71)and the combined group(escharectomy and skin grafting combined with rh-bFGF,n=71)according to the different treatment method.The operation condition,skin graft survival rate,inflammatory reactions,allergic reactions,wound tissue fibroblast(FB)and capillary count were compared between the two groups.Results The mean operative area in the combined group was not significantly different from that in the control group [(17.81±4.92)% vs(17.39±4.86)% ](P>0.05).The skin survival rate of the combined group was significantly higher than that of the control group(100% vs 91.55%)(P<0.05).The healing rate of the combined group at 15 d and 20 d was significantly higher than that of the control group(P<0.05),and the average healing time was significantly shorter than that of the control group(P<0.05).The positive rate of inflammatory reactions in the control group was higher than that in the combined group(P<0.05),and there was no significant difference in the positive rate of allergic reactions between the two groups(P>0.05).The number of FB and capillaries in the wound showed an upward trend(P<0.05),and the number of FB and capillaries in the wound tissues at 14 d and 21 d after operation in the combined group was significantly higher than that in the control group(P<0.05).Conclusion Emergency escharectomy and skin grafting combined with rh-bFGF can reduce the wounds inflammatory reaction,and promote the FB proliferation and angiogenesis and accelerate the healing of wounds in the patients with middle and small area deep burn.
作者
韩贝贝
李志超
胡东涛
Han Beibei;Li Zhichao;Hu Dongtao(Emergency Department of Sanmenxia Central Hospital,Sanmenxia 472000,China)
出处
《哈尔滨医药》
2021年第6期30-32,共3页
Harbin Medical Journal
