摘要
目的观察杨毓华教授验方强脊方治疗强直性脊柱炎疗效,以及对AS患者Th17细胞(T helpcell 17,Th17)及相关因子IL-6、IL-23的影响。方法患者分为验方中药组与柳氮磺嘧啶对照组,分别用药治疗2月。对中药组和对照组所有患者治疗前后进行强直性脊柱炎疾病活动度评分,C反应蛋白、血沉、HLA-B27检测,观察两组患者临床疗效。对所有病例治疗前进行抽血采样,流式细胞术检测Th17细胞数量;酶联免疫吸附法相关细胞因子IL-6、IL-23。治疗2月后再次进行抽血采样,组间进行标本对比分析。结果治疗前后两组患者各项指标及Th17细胞数量均明显下降(P<0.05),并且两组之间无明显差异(P>0.05)。结论杨毓华教授验方强脊方可以减少AS患者Th17细胞及相关因子IL-6、IL-23,从而起到治疗作用,其疗效与柳氮磺嘧啶无明显差异。
Objective To observe the efficacy of Professor YANG Yuhua’s prescription Qiangji formula in the treatment of ankylosing spondylitis(AS) and its effect on Th17 cells and related factors IL-6 and IL-23 in patients with AS.Methods Patients were divided into the prescription traditional Chinese medicine group and the sulfasalazine control group, which were treated for 2 months respectively.All patients in the traditional Chinese medicine group and the control group were scored for disease activity of ankylosing spondylitis before and after treatment(ASDAS),C-reactive protein, ESR and HLA-B27 were detected to observe the clinical efficacy of the two groups.Blood samples were taken from all cases before treatment, and the number of Th17 cells was detected by flow cytometry;enzyme-linked immunosorbent assay(ELISA) related cytokines IL-6 and IL-23.Blood samples were taken again after 2 months of treatment, and samples were compared and analyzed between groups.Results All indexes and the number of Th17 cells in the two groups decreased significantly before and after treatment(P<0.05),And there was no significant difference between the two groups(P>0.05).Conclusion Professor YANG Yuhua’s prescription Qiangji recipe can reduce Th17 cells and related factors IL-6 and IL-23 in patients with AS,so as to play a therapeutic role, and its curative effect is not significantly different from that of sulfasalazine.
作者
李江
徐斌
乔治
谭龙旺
LI Jiang;XU Bin;QIAO Zhi;TAN Longwang(Affiliated Hospital of Shaanxi University of traditional Chinese medicine,Shaanxi Xianyang 712000,China;Xi'an Fifth People's Hospital,Xi'an 710000,China)
出处
《陕西中医药大学学报》
2022年第1期88-92,共5页
Journal of Shaanxi University of Chinese Medicine
基金
国家自然科学基金项目(81774349)。
