摘要
目的探讨雷尼替丁和西米替丁两种药物治疗急性胃炎的疗效。方法106例急性胃炎患者,根据治疗方法的不同分为对照组与试验组,各53例。两组均进行常规治疗,在此基础上,对照组采取西咪替丁治疗,试验组应用雷尼替丁治疗。比较两组患者临床疗效、治疗前后炎性因子水平及不良反应发生情况。结果试验组患者总有效率100.00%高于对照组的84.91%,差异有统计学意义(P<0.05)。试验组患者不良反应发生率3.77%低于对照组的28.30%,差异具有统计学意义(P<0.05)。治疗后,试验组患者超敏C反应蛋白(6.21±1.20)mg/L、肿瘤坏死因子-α(1.45±0.21)ng/ml低于对照组的(9.31±2.20)mg/L、(2.35±0.56)ng/ml,差异具有统计学意义(P<0.05)。结论雷尼替丁在急性胃炎患者治疗中能够获得显著临床效果,其疗效和安全性均高于西咪替丁,可控制炎性因子,值得推广。
Objective To discuss the efficacy of ranitidine and cimetidine in the treatment of acute gastritis.Methods A total of 106 patients with acute gastritis were divided into control group and test group according to different treatment methods,with 53 cases in each group.Both groups received conventional treatment.On this basis,the control group was treated with cimetidine and the test group was treated with ranitidine.The clinical efficacy,levels of inflammatory factors before and after treatment,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 100.00% in the test group was higher than 84.91% in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 3.77% in the test group was lower than 28.30% in the control group,and the difference was statistically significant(P<0.05).After treatment,the high-sensitivity C-reactive protein(6.21±1.20)mg/L and tumor necrosis factor-α(1.45±0.21)ng/ml in the test group were lower than(9.31±2.20)mg/L,(2.35±0.56)ng/ml in the control group,and the difference was statistically significant(P<0.05).Conclusion Ranitidine has significant clinical effect on patients with acute gastritis,and its efficacy and safety are higher than those of cimetidine,which can control inflammatory factors and is worth promoting.
作者
秦桐
QIN Tong(Yingkou People’s Government Office Health Center,Yingkou 115000,China)
出处
《中国现代药物应用》
2022年第2期161-163,共3页
Chinese Journal of Modern Drug Application
