摘要
目的应用枸橼酸铋雷尼替丁(RBC)与克拉霉素+阿莫西林三联7d疗法根除幽门螺杆菌(Hp),评估以RBC为基础的三联方案的疗效。方法萎缩性胃炎120例随机分为R组和O组,每组60例,R组为RBC 350 mg+克拉霉素0.5 g+阿莫西林1 g,2次/d,口服;O组为奥美拉唑(OME)20 mg+克拉霉素0.5 g+阿莫西林1 g,2次/d,口服,疗程均为7 d。停药28 d后检查14C尿素呼气试验,如阴性表示根除成功,观察两组Hp阴转率。结果两组Hp阴转率分别为83.02%和71.15%,差异无统计学意义(P>0.05)。结论 R组根除萎缩性胃炎患者Hp感染,其Hp阴转率与O组相当。
Objective To compare the eradication rates in helicobacter pylori（Hp） infection of two triple therapies. Methods One hundred and twenty patients with chronic atrophic gastritis were randomized into two groups. Group R was given with ranitidine bismuth citrate（RBC） 350 mg bid plus clarithromycin 0.5 g bid and amoxicillin 1.0 g bid pofor one week. Group 0 was treated with omeprazole 20 mg bid plus clarithromycin 0.5 g bid and amoxicillin 1.0 g bid pofor one week. Rapid urease test was repeated one month after anti-HP therapy. Results The eradiation rates of group Rand group O were 83.02% and 71.15% ,respectively. No signifi- cant difference was found between two groups （ P 〉 0.05 ）. Conclusion The regimen of triple therapy with RBC is good as regimen with OME for the clinical eradication of Hp infection.
出处
《东南国防医药》
2013年第1期27-29,共3页
Military Medical Journal of Southeast China
关键词
枸橼酸铋雷尼替丁
三联疗法
幽门螺杆菌
萎缩性胃炎
ran ranitidine bismuth citrate
triple therapies
helicobacter pylori （Hp）
atrophic gastritis
