摘要
目的研究丙泊酚联合依托咪酯麻醉对卵巢癌手术患者血流动力学的影响。方法 60例卵巢癌手术患者,随机分为对照组和试验组,各30例。对照组采取传统麻醉,试验组采取丙泊酚联合依托咪酯麻醉。比较两组患者插管即刻收缩压、舒张压、心率变化及Coopers评分、肌电图(EMG)评分、肌松效应起效时间、拔管时间、恢复定向力时间。结果试验组患者插管即刻收缩压(126.20±1.57)mm Hg(1 mm Hg=0.133 kPa)、舒张压(67.20±0.42)mm Hg以及心率(69.50±0.21)次/min均优于对照组的(117.64±1.52)mm Hg、(62.90±0.37)mm Hg、(65.80±0.18)次/min,差异有统计学意义(P<0.05)。试验组患者Coopers评分(2.15±0.12)分、EMG评分(6.50±1.70)分、肌松效应起效时间(100.20±4.20)s、拔管时间(14.45±1.70)min、恢复定向力时间(15.22±1.02)min均优于对照组的(2.01±0.11)分、(15.57±1.70)分、(120.20±3.90)s、(23.11±1.57)min、(24.05±1.13)min,差异有统计学意义(P<0.05)。结论将丙泊酚联合依托咪酯麻醉应用于卵巢癌手术患者中,可有效维持血流动力学稳定,预防脑血管不良事件的发生,值得推广。
Objective To investigate the effects of anesthesia with propofol combined with etomidate on hemodynamics in patients undergoing surgery for ovarian cancer. Methods 60 patients with ovarian cancer were randomly divided into control group and experimental group, with 30 cases in each group. Patients in the control group were treated with traditional anesthesia, while patients in the experimental group were anaesthetized with propofol combined with etomidate. The changes of systolic blood pressure, diastolic blood pressure, heart rate,Cooper score, electromyography(EMG) score, onset time of muscle relaxation effect, extubation time and recovery time of orientation were compared between the two groups. Results The experimental group had systolic blood pressure of(126.20±1.57) mm Hg(1 mm Hg = 0.133 kPa), diastolic blood pressure of(67.20±0.42) mm Hg and heart rate of(69.50±0.21) beats/min, which were better than(117.64±1.52) mm Hg,(62.90±0.37) mm Hg and(65.80±0.18) beats/min of the control group, respectively;and the differences were statistically significant(P<0.05). The experimental group had Cooper score of(2.15±0.12) points, EMG score of(6.50±1.70) points,onset time of muscle relaxation effect of(100.20±4.20) s, extubation time of(14.45±1.70) min and recovery time of orientation of(15.22±1.02) min, which were better than(2.01±0.11) points,(15.57±1.70) points,(120.20±3.90) s,(23.11±1.57) min and(24.05±1.13) min of the control group, respectively;and the differences were statistically significant(P<0.05). Conclusion Anesthesia with propofol combined with etomidate anesthesia in patientsndergoing surgery for ovarian cancer may effectively maintain hemodynamic stability and prevent cerebrovascular adverse events. Thus, it is worth promoting.
作者
寇卜伟
KOU Bu-wei(Department of Anesthesiology,Shenyang Maternal and Child Health Hospital,Shenyang 110000,China)
出处
《中国现代药物应用》
2022年第1期137-139,共3页
Chinese Journal of Modern Drug Application
