摘要
目的:探讨醋酸奥曲肽辅助治疗对重症急性胰腺炎的效果及对氧化应激水平的影响。方法:选取茂名市中医院2018年1月至2021年5月期间收治的101例重症急性胰腺炎患者,按照随机数字表法分为对照组(50例)和观察组(51例)。对照组给予双歧杆菌三联活菌治疗,观察组在对照组基础上给予醋酸奥曲肽治疗,观察两组患者临床疗效、炎症因子水平、氧化应激水平。结果:治疗后,观察组患者治疗总有效率(94.11 %)高于对照组(80.00 %),差异具有统计学意义(P<0.05);治疗后,两组患者白细胞(WBC)以及C反应蛋白(CRP)水平均降低,且观察组患者WBC以及CRP水平均低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者超氧化物歧化酶(SOD)、丙二醛(MDA)水平均有所改善,且观察组患者SOD水平高于对照组,MDA水平低于对照组,差异具有统计学意义(P<0.05)。结论:醋酸奥曲肽辅助治疗重症急性胰腺炎,通过改善氧化应激水平,调节炎症因子水平,从而提高临床疗效。
Objective To investigate the effect of octreotide acetate assisted in adjuvant treatment of severe acute pancreatitis and the effect on oxidative stress level.Methods A total of 101 patients with severe acute pancreatitis admitted to Maoming Hospital of Traditional Chinese Medicine from January 2018 to May 2021 were selected and divided into control group with 50 cases and observation group with 51 cases according to random number table method.The control group was given bifid-triple viable capsule treatment,and the observation group was given octreotide acetate treatment on the basis of the control group.The clinical efficacy,inflammatory factor level and oxidative stress level of patients in the two groups were observed.Results After treatment,the total effective rate of the observation group(94.11%) was higher than that of control group (80.00%),and the difference was statistically significant (P < 0.05);After treatment,white blood cells (WBC) and C reactive protein (CRP) levels were both decreased,and the WBC and CRP levels in the observation group were lower than those in the control group,and the differences were statistically significant (P < 0.05);After treatment,the SOD,MDA levels in two groups of patients were improved,and SOD level in the observation group was higher than that in the control group,and the MDA level was lower than that in control group,and the differences were statistically significant (P < 0.05).Conclusion Octreotide acetate in the adjuvant treatment of severe acute pancreatitis can improve the clinical efficacy by improving oxidative stress level and regulating inflammatory factor level.
作者
莫振晓
张奇增
MO Zhen-xiao;ZHANG Qi-zeng(Maoming Hospital of Traditional Chinese Medicine,Guangdong Maoming 525000)
出处
《深圳中西医结合杂志》
2021年第20期158-160,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
