摘要
目的:探讨奥曲肽联合腹腔镜肠粘连松解术对粘连性肠梗阻患者的影响。方法:选取2021年2月—2022年2月浠水县人民医院收治的60例粘连性肠梗阻患者。根据随机数表法将其分为对照组和观察组,各30例。全部患者均接受常规处理,对照组接受腹腔镜肠粘连松解术治疗,观察组接受奥曲肽联合腹腔镜肠粘连松解术治疗。比较两组临床疗效、时间指标,术前及术后3 d炎症因子、氧化应激指标及生活质量评分。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组肛门排气时间、肠蠕动恢复时间、住院时间均短于对照组,差异有统计学意义(P<0.05)。术后3 d,观察组谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)和超氧化物歧化酶(superoxide dismutase,SOD)水平均高于对照组,降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)与白细胞介素-6(interleukin-6,IL-6)、丙二醛(malondialdehyde,MDA)水平均低于对照组,差异有统计学意义(P<0.05)。术后3 d,观察组健康调查简表(SF-36)评分高于对照组,差异有统计学意义(P<0.05)。结论:奥曲肽联合腹腔镜肠粘连松解术可提升粘连性肠梗阻的治疗效果,加快胃肠功能恢复,降低炎症因子水平,缓解氧化应激反应,提高患者生活质量。
Objective:To investigate the effect of Octreotide combined with laparoscopic intestinal adhesiolysis on patients with adhesive ileus.Method:Sixty patients with adhesive ileus admitted to Xishui County People's Hospital from February 2021 to February 2022 were selected.They were divided into control group and observation group according to random number table method,with 30 cases in each group.All patients received routine treatment,the control group received laparoscopic intestinal adhesiolysis treatment,the observation group received Octreotide combined with laparoscopic intestinal adhesiolysis treatment.The clinical efficacy,time indexes,inflammatory factors,oxidative stress indexes and quality of life score before and 3 d after surgery were compared between the two groups.Result:The treatment total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The time of anal exhaust,recovery time of intestinal peristalsis and hospital stay in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).At 3 d after surgery,glutathione peroxidase(GSH-Px)and superoxide dismutase(SOD)levels in the observation group were higher than those in the control group,and the levels of procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6),and malondialdehyde(MDA)were lower than those in the control group,and the differences were statistically significant(P<0.05).At 3 d after surgery,the MOS item short from health survey(SF-36)score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Octreotide combined with laparoscopic intestinal adhesiolysis can improve the therapeutic effect of adhesive ileus,accelerate the recovery of gastrointestinal function,reduce the level of inflammatory factors,relieve oxidative stress response,and improve the quality of life of patients.
作者
南政
NAN Zheng(Xishui County People's Hospital,Xishui 438200,China)
出处
《中外医学研究》
2023年第27期49-52,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
粘连性肠梗阻
腹腔镜手术
奥曲肽
胃肠功能
炎症因子
氧化应激反应
Adhesive ileus
Laparoscopic surgery
Octreotide
Gastrointestinal function
Inflammatory cytokines
Oxidative stress reaction
