摘要
探究中药提取物空间构造性质与吸湿性的相关性及抗吸湿技术。以茯苓提取物为模型药物,在中药提取物流浸膏中加入不同比例的预胶化淀粉及微晶纤维素,利用不同干燥工艺制造不同空间构造的粉体粒子。用平衡吸湿率(F^(∞))及半吸湿时间(t_(1/2))表征其吸湿行为,采用偏最小二乘法分析各粉体的吸湿性与粒径(D_(90))、孔隙率(ε)、真密度(ρ_(t))、表面元素分布等空间构造性质的相关性。3种干燥方法所制备的茯苓提取物的F^(∞)喷雾>常压>减压;t_(1/2)减压>常压>喷雾。喷雾干燥所得粉体呈现球形结构,粒径和粒子内ε最小,吸湿性较强。减压干燥粉体表面元素大量富集效应有效降低了粉体的吸湿性。F^(∞)、t_(1/2)分别与ε呈负相关,与D_(90)呈正相关,各空间构造性质的交互影响不显著。中药提取物粉体粒子的空间构造与吸湿性存在相关性,通过设计空间构造可以改善吸湿性,该研究为中药制剂的防潮技术提供了一定的实践依据。
This study was designed to investigate the correlations of the spatial structure properties of Chinese medicinal extracts with hygroscopicity and the anti-hygroscopic techniques.With Poria extract used as the model drug,pregelatinised starch and microcrystalline cellulose at different ratios were added into Poria fluid extract for preparing powder particles with diverse spatial structures using different drying processes.Then,their hygroscopic behaviours were characterized by equilibrium hygroscopicity(F^(∞))and semi-hygroscopic time(t_(1/2)).The correlations of the hygroscopicity of each powder with the spatial structure properties such as particle size(D_(90)),porosity(ε),true density(ρ_(t)),and surface element distribution were analyzed using partial least-squares method.The F^(∞) and t_(1/2) values of Poria extract prepared by three drying methods were sorted in a descending order as follows:F^(∞)(spray drying>drying at ordinary pressure>drying at reduced pressure);t_(1/2)(drying at reduced pressure>drying at ordinary pressure>spray drying).The powder obtained by spray drying showed a spherical structure with the smallest particle size and intra-particleεbut relatively stronger hygroscopicity.The large-scale surface element enrichment of the powders dried by reduced pressure effectively reduced their hygroscopicity.F^(∞) and t_(1/2) were negatively correlated withεbut positively with D_(90),and the interactive influence of each spatial structural properties was not significant.There existed a correlation between the spatial structure of the powder particles of Chinese medicine extracts and their hygroscopicity,and the hygroscopicity could be improved by designing the spatial structure.This study has provided some practical basis for developing the moisture-proof technology of Chinese medicinal preparations.
作者
赵樱霞
熊志伟
胡晓欣
宁汝曦
封亮
贾晓斌
ZHAO Ying-xia;XIONG Zhi-wei;HU Xiao-xin;NING Ru-xi;FENG Liang;JIA Xiao-bin(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第23期6020-6027,共8页
China Journal of Chinese Materia Medica
基金
国家重点研发计划“中医药现代化研究”专项(2018YFC1706900)
中国药科大学双一流建设创新团队项目(CPU2018GY11,CPU2018GF07)。
关键词
中药提取物
吸湿性
表征
空间构造
相关性
粒子设计
Chinese medicinal extract
hygroscopicity
characterization
spatial structure
correlation
particle design
