摘要
目的探讨血清脂质运载蛋白-2(Lipocalin-2)、癌胚抗原(CEA)和糖类抗原125(CA125)联合检测对肺癌的诊断价值。方法选取2020年1—12月于本院就医的54例确诊肺癌患者及60名健康体检者作为试验组及对照组。采用ELISA法检测血清Lipocalin-2水平,用罗氏cobas8000全自动生化分析仪检测CEA和CA125含量,并计算受试者工作特性曲线(ROC曲线)。结果肺癌患者血清Lipocalin-2(239.04±98.15)ng/mL、CEA(6.04±5.21)ng/mL和CA125(25.64±22.98)U/mL的浓度均显著高于健康体检人群(P<0.05)。肺癌患者血清Lipocalin-2、CEA和CA125及三者联合检测ROC曲线下面积分别为0.848、0.744、0.784及0.970,三者联合检测的诊断效能显著高于三者单独及CEA+CA125联合的诊断效能。结论血清Lipocalin-2、CEA和CA125水平对肺癌的诊断有重要意义,联合检测可显著提高肺癌的诊断效率。
Objective To explore the diagnostic value of combined detection of serum lipocalin-2,carcinoembryonic antigen(CEA)and carbohydrate antigen 125(CA125)in lung cancer(LC).Methods A total of 54 patients confirmed as lung cancer and 60 healthy people admitted to our hospital from January to December 2020 were selected as the experimental group and control group.Serum Lipocalin-2 level was detected by ELISA,CEA and CA125 content were detected by cobas8000 automatic biochemical analyzer(Roche),and the receiver operating characteristic(ROC)curve was calculated.Results The levels of serum Lipocalin-2(239.04±98.15)ng/mL,CEA(6.04±5.21)ng/mL and CA125(25.64±22.98)U/mL in LC patients were significantly higher than those in healthy people(P<0.05).The areas under the ROC curve of serum Lipocalin-2,CEA and CA125 in LC patients were 0.848,0.744,0.784 and 0.970,respectively.The diagnostic efficiency of the combined detection of the three indexes was significantly higher than that of the combined detection of the three alone and the combined detection of CEA and CA125.Conclusion Serum levels of Lipocalin-2,CEA and CA125 are important for the diagnosis of LC,and combined detection can significantly improve the diagnostic efficiency of LC.
作者
黄远虹
张知
刘小勇
HUANG Yuanhong;ZHANG Zhi;LIU Xiaoyong(Department of Clinical Laboratory,Ganzhou Municipal Hospital in Jiangxi Province,Ganzhou 341000,China)
出处
《中国现代医生》
2021年第33期146-149,F0003,共5页
China Modern Doctor
关键词
脂质运载蛋白-2
癌胚抗原
糖类抗原125
肺癌
联合检测
Lipocalin-2
Carcinoembryonic antigen
Carbohydrate antigen 125
Lung cancer
Combined detection
