摘要
目的探究肿瘤标志物癌胚抗原(CEA)、甲胎蛋白(AFP)、糖类抗原199(CA199)、糖类抗原125(CA125)在卵巢肿瘤良恶性鉴别诊断中的应用价值。方法以2015年1月至2020年1月收治的120例卵巢肿瘤患者为试验组,同时选取50名健康体检者为对照组,均实施CEA、AFP、CA199、CA125水平检测,并分析检测结果。结果试验组不同类型患者的CEA、AFP、CA199、CA125水平高于对照组,差异具有统计学意义(P<0.05);卵巢恶性肿瘤患者的CEA、AFP、CA199、CA125水平高于卵巢良性肿瘤患者,差异具有统计学意义(P<0.05)。试验组不同类型患者的AFP、CA199、CA125阳性率高于对照组,差异具有统计学意义(P<0.05);卵巢恶性肿瘤患者的CEA、AFP、CA199、CA125阳性率高于卵巢良性肿瘤患者,差异具有统计学意义(P<0.05)。CEA、AFP、CA199、CA125联合检测对卵巢恶性肿瘤的诊断灵敏度为88.68%,特异度为94.03%,准确度为91.67%,阴性预测值为91.30%,阳性预测值为92.16%。结论CEA、AFP、CA199、CA125联合检测能够较好地对卵巢肿瘤疾病性质进行鉴别诊断,为后续治疗奠定基础,值得推广应用。
Objective To explore the application value of tumor markers carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),carbohydrate antigen 199(CA199)and carbohydrate antigen 125(CA125)in the differential diagnosis of benign and malignant ovarian tumors.Methods A total of 120 patients with ovarian tumors admitted from January 2015 to January 2020 were selected as experimental group,and 50 healthy subjects were selected as control group.Levels of CEA,AFP,CA199 and CA125 of all objects were detected,and the results were analyzed.Results The levels of CEA,AFP,CA199 and CA125 in different types of patients in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05);the levels of CEA,AFP,CA199 and CA125 in patients with malignant ovarian tumors were higher than those in patients with benign ovarian tumors,and the differences were statistically significant(P<0.05).The positive rates of AFP,CA199 and CA125 in different types of patients in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05);the positive rates of CEA,AFP,CA199 and CA125 in patients with malignant ovarian tumors were higher than those in patients with benign ovarian tumors,and the differences were statistically significant(P<0.05).The sensitivity,specificity,accuracy,negative predictive value and positive predictive value of CEA,AFP,CA199 and CA125 combined detection for malignant ovarian tumors were 88.68%,94.03%,91.67%,91.30% and 92.16%,retrospectly.Conclusion The combined detection of CEA,AFP,CA199 and CA125 can better distinguish the nature of ovarian tumor and lay a foundation for follow-up treatment,which is worthy of clinical promotion and application.
作者
夏润
张洒
何晨光
XIA Run;ZHANG Sa;HE Chenguang(Weinan Maternal and Child Health Hospital,Weinan 714000;Dali County Maternal and Child Health Hospital,Weinan 715100,China)
出处
《临床医学研究与实践》
2021年第36期133-135,共3页
Clinical Research and Practice
关键词
卵巢肿瘤
肿瘤标志物
癌胚抗原
甲胎蛋白
糖类抗原199
糖类抗原125
ovarian tumor
tumor marker
carcinoembryonic antigen
alpha-fetoprotein
carbohydrate antigen 199
carbohydrate antigen 125
