摘要
目的探讨血清胃蛋白酶原(PG)Ⅰ、PGⅠ/Ⅱ联合肿瘤标志物癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原125(CA125)在胃癌诊断中的价值。方法选取2019年1月至2020年12月阳江市人民医院经病理活检确诊的80例胃癌患者作为胃癌组,选取同期确诊的80例胃良性病变患者作为良性病变组,选取同期60例健康体验者作为对照组。比较三组的PGⅠ、PGⅠ/Ⅱ、CEA、CA199、CA125水平差异及单一检测与联合检测的敏感度、特异度、准确度。结果胃癌组的PGⅠ、PGⅠ/Ⅱ低于良性病变组与对照组,差异有统计学意义(P<0.05)。胃癌组的CEA、CA199、CA125水平高于良性病变组与对照组,差异有统计学意义(P<0.05)。在胃癌组中,联合检测的敏感度、准确度均高于单一检测,差异有统计学意义(P<0.05);特异度虽有所下降,但基本保持良好。结论PGⅠ、PGⅠ/Ⅱ、CEA、CA199、CA125联合检测具有较高的敏感度、准确度与良好的特异度,可提升胃癌诊断效能。
Objective To explore the value of serum pepsinogen(PG)Ⅰ,PGⅠ/Ⅱcombined with tumor markers carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199)and cancer antigen 125(CA125)in the diagnosis of gastric cancer.Methods Eighty patients with gastric cancer diagnosed by pathological biopsy from People′s Hospital of Yangjiang City from January 2019 to December 2020 were selected as the gastric cancer group,80 patients with benign gastric lesions diagnosed at the same time were selected as the benign lesion group,and 60 healthy experiencers were selected as the control group.The levels of PGⅠ,PGⅠ/Ⅱ,CEA,CEA,CA199,CA125 and the sensitivity,specificity and accuracy of single detection and combined detection were compared among the three groups.Results The PGⅠand PGⅠ/Ⅱin the gastric cancer group were lower than those of the benign lesion group and the control group,and the differences were statistically significant(P<0.05).The levels of CEA,CA199,and CA125 in the gastric cancer group were higher than those of the benign lesion group and the control group,and the differences were statistically significant(P<0.05).In gastric cancer group,the sensitivity and accuracy of combined detection were higher than those of single detection,and the differences were statistically significant(P<0.05).The specificity decreased but remained good.Conclusion The combine detection of PGⅠ,PGⅠ/Ⅱ,CEA,CA199,and CA125 has high sensitivity,accuracy and good specificity,which can improve the diagnostic efficiency of gastric cancer.
作者
林荣军
陈振奋
杨丽萍
陈冬玲
黎杨杨
LIN Rong-jun;CHEN Zhen-fen;YANG Li-ping;CHEN Dong-ling;LI Yang-yang(Department of Laboratory Medicine,People′s Hospital of Yangjiang City,Guangdong Province,Yangjiang529500,China)
出处
《中国当代医药》
CAS
2021年第35期184-186,共3页
China Modern Medicine
基金
广东省阳江市医疗卫生类科技计划项目(社发〔2017〕22)。
关键词
胃癌
胃蛋白酶原
癌胚抗原
糖类抗原199
糖类抗原125
敏感度
特异度
Gastric cancer
Pepsinogen
Carcinoembryonic antigen
Carbohydrate antigen 199
Glycoprotein antigen 125
Sensitivity
Specificity
