摘要
目的探讨川崎病并发冠状动脉损害(CALs)患儿血清C反应蛋白(CRP)、血小板计数(PLT)及羧化不全骨钙素(ucOC)水平及意义。方法选取2017年9月至2019年9月在我院治疗的川崎病患儿72例为观察组,同期选取健康体检儿童70例作为对照组。检测血清CRP、PLT及ucOC水平,采用超声心动图检查川崎病患儿CALs发生情况。结果观察组CRP和PLT明显高于对照组,ucOC明显低于对照组,差异有统计学意义(P<0.05);经超声心动图检查,有25例患儿伴有CALs;观察组伴CALs患儿CRP明显高于不伴CALs患儿,ucOC水平明显低于不伴CALs患儿,差异有统计学意义(P<0.05);观察组伴和不伴CALs患儿PLT比较差异无统计学意义(P>0.05);CRP、ucOC诊断川崎病患儿伴CALs的ROC曲线下面积分别为0.701和0.651(P<0.05),截断值分别为74.69 mg/L和12.36μg/L,灵敏性分别为48.00%和52.00%,特异性分别为87.23%和89.36%。结论川崎病并发CALs患儿CRP、PLT及ucOC水平升高,其中CRP和ucOC在诊断川崎病并发CALs中有一定应用价值。
Objective To investigate the serum C-reactive protein(CRP)level,platelet count(PLT)and undercarboxylated osteocalcin(ucOC)levels in children with Kawasaki disease complicated with coronary artery lesions(CALs)and its significance.Methods Totally 72 cases(observation group)of children with Kawasaki disease treated in our hospital from September 2017 to September 2019 were selected,and 70 healthy children receiving physical examination during the same period were selected as the control group.The serum CRP,PLT and ucOC levels were detected,and the occurrence of CALs in children with Kawasaki disease was examined by echocardiography.Results The CRP and PLT in the observation group were significantly higher than those in the control group(P<0.05),while ucOC was significantly lower than those in the control group(P<0.05).There were 25 children with CALs by echocardiography.In the observation group,CRP in children with CALs was significantly higher than that in children without CALs(P<0.05),while ucOC was significantly lower(P<0.05).There was no significant difference in PLT between children with and those without CALs in observation group(P>0.05).The area under ROC curve of CRP and ucOC in diagnosing Kawasaki disease with CALs was 0.701 and 0.651(P<0.05).Cut-off values were 74.69 mg/L and 12.36 g/L,the sensitivity was 48.00% and 52.00%,and specificity was 87.23% and 89.36%,respectively.Conclusion CRP,PLT and ucOC levels are increased in children with Kawasaki disease complicated with CALs,among which CRP and ucOC has certain application value in diagnosing Kawasaki disease complicated with CALs.
作者
李淑娟
梁宏
陈晓轶
LI Shujuan;LIANG Hong;CHEN Xiaoyi(Children's Hospital Affiliated to Zhengzhou University,Zhengzhou 450018,China)
出处
《中国中西医结合儿科学》
2021年第6期496-499,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
河南省医学科技攻关项目(2018020695)。
关键词
川崎病
冠状动脉损害
C反应蛋白
血小板计数
羧化不全骨钙素
儿童
Kawasaki disease
Coronary artery lesion
C-reactive protein
Platelet count
Undercarboxylated osteocalcin
Children
