摘要
目的探讨不同剂量静注人免疫球蛋白(pH4)对川崎病合并冠状动脉损伤患儿外周血CD4^+CD25^+调节性T细胞、转化生长因子-β(transforming growth factor-β,TGF-β)、白介素-10(interleukin-10,IL-10)、基质金属蛋白酶9(matrix metalloproteinases-9,MMP-9)、抗内皮细胞抗体(anti endothelial cell antibody,AECA)、抗中性粒细胞胞质抗体(antineutrophil cytoplasmic antibody,ANCA)的影响。方法选择2014年1月至2018年1月本院收治的62例川崎病合并冠状动脉损伤的患儿为研究对象,采用随机数表法将其分为观察组(31例)和对照组(31例)。对照组患儿采用常规剂量静注人免疫球蛋白(pH4)联合阿司匹林治疗,观察组患儿采用大剂量静注人免疫球蛋白(pH4)联合阿司匹林治疗,比较两组患儿治疗前后CD4^+CD25^+调节性T细胞、TGF-β、IL-10、MMP-9、AECA、ANCA水平。结果治疗后,两组患儿CD4^+CD25^+调节性T细胞及TGF-β水平均显著高于治疗前(P均<0.05),MMP-9、AECA、ANCA、IL-10水平均显著低于治疗前(P均<0.05)。观察组患儿CD4^+CD25^+调节性T细胞及TGF-β水平均显著高于对照组(P均<0.05),MMP-9、AECA、ANCA、IL-10水平均显著低于对照组(P均<0.05)。结论 CD4^+CD25^+调节性T细胞、TGF-β、IL-10、MMP-9、AECA、ANCA参与了川崎病合并冠状动脉损伤的发生发展,监测其水平变化对预测患儿早期冠状动脉损伤具有重要意义,大剂量静注人免疫球蛋白(pH4)有利于改善患儿机体免疫功能和炎症状态。
Objective To investigate the effects of different doses of Human immunoglobulin（pH4） for intravenous injection on peripheral blood CD4~＋CD25~＋ regulatory T cells, interleukin-10（IL-10）, transforming growth factor-β（TGF-β）, matrix metalloproteinases-9（MMP-9）, anti endothelial cell antibody（AECA） and antineutrophil cytoplasmic antibody（ANCA） in children with Kawasaki disease（KD） complicated with coronary artery lesions. Method From January 2014 to January 2018, 62 children with KD complicated with coronary artery lesions were selected as objects of study. All the children were randomly divided into observation group（n = 31） and control group（n = 31） by the random number method. Control group children were treated with conventional dose of Human immunoglobulin（pH4） for intravenous injection combined with Aspirin, while observation group children were treated with high-dose Human immunoglobulin（pH4） for intravenous injection combined with Aspirin.The levels of CD4~＋CD25~＋ regulatory T cells, IL-10, TGF-β, MMP-9, AECA and ANCA were compared before and after treatment between the two groups. Result After treatment, the expression levels of CD4~＋CD25~＋ regulatory T cells and TGF-β in the two groups were significantly higher than those before treatment（Pall 0.05）, while the expression levels of MMP-9, AECA, ANCA and IL-10 were significantly lower than those before treatment（Pall 0.05）. The expression levels of CD4~＋CD25~＋ regulatory T cells and TGF-β in observation group were significantly higher than those in control group（Pall 〈0.05）, and the expression levels of MMP-9, AECA, ANCA and IL-10 were significantly lower than those in control group（Pall 〈0.05）. Conclusion CD4~＋CD25~＋ regulatory T cells, IL-10, TGF-β, MMP-9, AECA and ANCA are involved in the occurrence and development of coronary artery lesions in children with KD. Monitoring the changes of them is of great significance in early prediction of coronary artery lesions in c
作者
喻婷婷
余静
YU Ting-ting;YU Jing(Department of Pediatrics,People＇s Hospital of China Three Gorges University,Yichang First People＇s Hospital,Hubei,Yichang 443002,Chin)
出处
《中国医学前沿杂志（电子版）》
2018年第8期30-33,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
基金
湖北省教育厅科研课题(B201404)
