摘要
目的:探讨年龄因素对肺结核合并下呼吸道感染患者各类型免疫细胞比率及病原菌分布的影响。方法:回顾性分析2016年1月至2020年5月无锡市第五人民医院收治的肺结核合并下呼吸道感染患者(结核组)113例,并选择同期进行健康体检者45例为对照组,根据结核组患者年龄分为老年组(年龄≥60岁)、中年组(年龄40~59岁)、青年组(年龄18~39岁)。采用流式细胞仪测定不同组CD3^(+)、CD4^(+)、CD8^(+)、NK细胞、B细胞比率。并收集老年组与中年组、青年组患者痰标本进行普通培养,比较感染病原菌分布。结果:与对照组比较,结核组中CD3^(+)、CD4^(+)、NK细胞、B细胞水平明显降低,CD8^(+)水平明显升高,差异有统计学意义(均P<0.05)。老年组CD3^(+)、CD4^(+)、NK细胞、B细胞水平明显低于中年组、青年组;CD8^(+)水平明显高于中年组、青年组,且差异均有统计学意义(均P <0.0 5)。除大肠埃希菌、金黄色葡萄球菌外,其余病原菌在老年组分布率均高于中年组、青年组,且差异均有统计学意义(均P<0.05)。结论:老年肺结核合并下呼吸道感染患者免疫功能低于中青年患者,且病原菌感染率高于中青年患者,应加强关注其免疫功能与病原菌感染情况。
Objective:To study the influence of age on the ratio of various types of immune cells and the distribution of pathogenic bacteria in patients with pulmonary tuberculosis complicated with lower respiratory tract infection.Methods:A retrospective analysis was performed on 113 patients with tuberculosis complicated with lower respiratory tract infection(tuberculosis group) admitted to Wuxi Fifth People’s Hospital from January 2016 to May 2020,and 45 healthy subjects who underwent physical examination during the same period were selected as the control group.According to the age of the tuberculosis group,the patients were divided into the elderly group(age ≥60 years),the middle-aged group(age 40–59 years),and the youth and middle-age group(age 18–39 years).Flow cytometry was used to determine the ratio of CD3^(+),CD4^(+),CD8^(+),NK cells and B cells in different groups.The sputum specimens of the elderly group,the young and middle-aged group were collected for common culture,and the distribution of infection pathogens were compared.Results:Compared with the control group,the levels of CD3^(+),CD4^(+),NK cells,B cells in the tuberculosis group were significantly reduced,and the level of CD8^(+) was significantly increased.The differences between the groups were statistically significant(all P<0.05).The levels of CD3^(+),CD4^(+),NK cells and B cells in the elderly group were significantly lower than those in the youth and middle-age group;the level of CD8^(+) was significantly higher than those in the youth and middle-age group,and the differences between the groups were statistically significant(all P<0.05).Except for Escherichia coli and Staphylococcus aureus,the distribution rate of other pathogens in the elderly group was higher than that in the young and middle-aged groups,and the differences between the groups were statistically significant(all P<0.05).Conclusion:Elderly patients with pulmonary tuberculosis and lower respiratory tract infection have lower immune function than young and middle-aged patient
作者
邵洁
秦香
秦小雯
周潇
SHAO Jie;QIN Xiang;QIN Xiaowen;ZHOU Xiao(Department of Tuberculosis,Wuxi Fifth People's Hospital,Wuxi Jiangsu 214000,China)
出处
《临床与病理杂志》
CAS
2021年第12期2812-2817,共6页
Journal of Clinical and Pathological Research
关键词
年龄
肺结核合并下呼吸道感染
免疫细胞
病原菌
age
tuberculosis with lower respiratory tract infection
immune cells
pathogenic bacteria
