摘要
鲍曼不动杆菌是一种革兰阴性菌,是重要的病原菌之一。由于抗生素的滥用,多重耐药鲍曼不动杆菌的检出率越来越高。抗菌肽作为细菌感染治疗的替代品,是从生物体中自然产生的,具有快速杀伤和高效广谱的抗菌活性。本文对人源、两栖动物源、昆虫源抗菌肽在治疗鲍曼不动杆菌感染中的作用、机制和应用前景进行综述。
Acinetobacter baumannii,a Gram-negative bacterium,is one of the most important pathogens.Due to the abuse of antibiotics,the detection rate of multi-drug resistant Acinetobacter baumannii is increasing.Antimicrobial peptides have been considered as alternatives to the treatment of bacterial infections,which are naturally produced from organisms,and have rapid killing and high-efficiency broad-spectrum antimicrobial activities.This paper reviewed the function,mechanism and application prospect of several kinds of antimicrobial peptides in the treatment of Acinetobacter baumannii.
作者
郭停停
陆超榕
高洁
开龙鑫
孙晓利
杨厉颖
焦红梅
孔桂美
李国才
GUO Tingting;LU Chaorong;GAO Jie;KAI Longxin;SUN Xiaoli;YANG Liying;JIAO Hongmei;KONG Guimei;LI Guocai(Medical College of Yangzhou University,Yangzhou,Jiangsu,225009;Jiangsu Basic and Clinical Transformation Key Laboratory of Non-coding RNA,Yangzhou,Jiangsu,225009;Jiangsu Collaborative Innovation Center for Prevention and Control of Important Animal Infectious Diseases Zoonoses,Yangzhou,Jiangsu,225001)
出处
《实用临床医药杂志》
CAS
2021年第19期123-127,132,共6页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金资助项目(82073611)
国家自然科学基金资助项目(82002186)
国家自然科学基金资助项目(81471906)
江苏省高等学校自然科学研究面上项目(19KJB310002)。
关键词
鲍曼不动杆菌
抗菌肽
抗菌活性
作用机制
Acinetobacter baumannii
antimicrobial peptides
antimicrobial activity
mechanism
