摘要
不明原因心脏性猝死(unexplained sudden cardiac death,USCD)常规病理学检验缺乏显著的形态学特征,法医学领域已借助分子生物学的方法通过检测基因来探寻死因,并开展心脏性猝死机制相关研究。从分子病理学角度,应用多个层面的生物标志物解析USCD的病因已初现潜力,为USCD的法医学鉴定提供了重要路径。本文概述了USCD相关的基因、RNA和蛋白质与USCD的最新研究进展及法医学应用初探。
Routine pathological examination of unexplained sudden cardiac death(USCD)lacks signifi-cant morphological characteristics.In the field of forensic medicine,molecular biology methods have been used to find the cause of death by detecting genes and research related to the mechanism of sud-den cardiac death has been carried out.From the molecular pathology point of view,the application of multiple levels of biomarkers to resolve the causes of USCD has already shown potential and pro-vides an important path for forensic identification of USCD.This article reviews the latest research progress on USCD-related genes,RNA,proteins and USCD,and summarizes forensic application.
作者
何享旺
李林峰
张付
云利兵
HE Xiang-wang;LI Lin-feng;ZHANG Fu;YUN Li-bing(West China School of Basic Medical Sciences&Forensic Medicine,Chengdu 610041,China;Key Laboratory of Forensic Pathology,Guangdong Public Security Department,Guangzhou 510050,China)
出处
《法医学杂志》
CAS
CSCD
2021年第5期687-693,共7页
Journal of Forensic Medicine
基金
法医病理学公安部重点实验室开放课题(GAFYBL201802)
四川大学2020年大学生创新创业训练计划资助项目(C2020111956)。
关键词
法医病理学
心脏性猝死
分子标志物
综述
forensic pathology
sudden cardiac death
molecular biomarker
review
