摘要
SCN5A基因变异所致心源性猝死发生机制尚不清楚。目前研究显示TGF-β1介导心肌纤维化以及离子通道重构调节机制的异常可能是SCN5A基因变异导致SUNDS发生的主要原因。本文就转化生长因子β1对SCN5A基因变异所致心源性猝死调控的影响机制研究进展进行综述,以期为心源性猝死法医学研究和实践提供参考。
The mechanism of sudden cardiac death caused by variation in SCN5 A is still unclear. Recently, the converging evidences suggest that the dysfunction of regulation mediated by transforming growth factor-β1 in cardiac fibration and reconstruction of cardiac iron channel could be main reason of SUNDS caused by variation of SCN5 A. The resent progress of the mechanism of transforming growth factor-β1 in sudden cardiac death caused by variation of SCN5 A gene is reviewed in this paper, hoping to provide reference for the research and practice of sudden cardiac death in forensic medicine.
出处
《中国法医学杂志》
CSCD
2017年第3期290-293,共4页
Chinese Journal of Forensic Medicine
基金
国家自然科学基金资助项目(81671866)
"十二五"国家重大科技攻关项目(2012BAK02B002)
上海市法医学重点实验室开放课题资助项目(2013KF1307)
广东省自然科学基金自由申请项目(2016A030313223)
