摘要
目的分析帕金森病(Parkinson s disease,PD)患者便秘的临床特点及相关影响因素,观察便秘对PD患者生活质量的影响。方法根据罗马Ⅲ功能性便秘诊断标准,将115例PD患者分为便秘组及无便秘组,统计PD患者便秘症状谱,分析PD患者便秘发生的危险因素,比较便秘组及无便秘组患者的生活质量。结果115例PD患者中便秘发生率为57.39%(66/115),症状主要为大便费力、排空不全、大便呈块状或硬条状、大便次数少于每周3次。便秘组年龄、UPDRSⅢ评分、HAMD评分、左旋多巴剂量及LDE高于无便秘组,日蔬菜摄入量及日饮水量低于无便秘组,差异均有统计学意义(P<0.05)。Logistic回归分析结果显示,年龄(OR=1.11)、HAMD评分(OR=1.27)、UPDRSⅢ评分(OR=1.08)、日饮水量(OR=0.998)、日蔬菜摄入量(OR=0.99)是PD患者发生便秘的影响因素(P<0.05)。便秘组患者PDQ-39评分高于无便秘组,ADL评分低于无便秘组,差异有统计学意义(P<0.05)。结论PD患者便秘发生率高,严重影响患者生活质量。年龄、HAMD评分、UPDRSⅢ评分是PD患者发生便秘的独立危险因素,日饮水量及日蔬菜摄入量是PD患者发生便秘的保护因素。
Objective To analyze the clinical characteristics and related influencing factors of constipation symptoms in patients with Parkinson’s disease(PD),and to observe the effect of constipation on quality of life of PD patients.Methods According to the RomeⅢfunctional constipation diagnostic criteria,115 PD patients were divided into constipation group and non-constipation group.The constipation symptom spectrum and the risk factors of constipation in PD patients were analyzed.And the quality of life of the constipation group and non-constipation group was compared.Results The incidence of constipation in 115 PD patients was 57.39%(66/115),and the main symptoms were laborious stools,incomplete emptying of stools,lumpy or hard stools,and less than 3 times of defecation per week.The age,UPDRSⅢscore,HAMD score,levodopa dose and LDE in constipation group were significantly higher than those in non-constipation group,while daily vegetable intake and daily water intake were significantly lower than those in non-constipation group,the differences were statistically significant(P<0.05).The Logistic regression analysis showed that age(OR=1.11),HAMD score(OR=1.27),UPDRSⅢscore(OR=1.08),daily water intake(OR=0.998)and daily vegetable intake(OR=0.99)were the influencing factors for constipation in PD patients(P<0.05).The PDQ-39 score in the constipation group was higher than that in the non-constipation group,and the ADL score was lower than that in the non-constipation group,and the differences were statistically significant(P<0.05).Conclusions PD patients had a high incidence of constipation,which seriously affected their quality of life.Age,HAMD score and UPDRSⅢscore were independent risk factors for constipation in PD patients,while daily water intake and daily vegetable intake were protective factors for constipation in PD patients.
作者
李洪奎
王晓宇
LI Hongkui;WANG Xiaoyu(Department of Neurology,Zhejiang Medical and Health Group Hangzhou Hospital,Hangzhou 310022,China)
出处
《健康研究》
CAS
2021年第6期678-681,693,共5页
Health Research
关键词
帕金森病
便秘
生活质量
Parkinson’s disease
constipation
quality of life
