摘要
目的利用孟德尔随机化探索血浆中支链氨基酸(亮氨酸、异亮氨酸和缬氨酸)与帕金森病(Parkinson’s disease,PD)的因果关系。方法从英国生物样本库中提取出31条与血浆中支链氨基酸浓度的显著相关的单核酸多态性(single nucleotide polymorphism,SNPs)(P<5×10^(-8)),并在芬兰生物样本库中帕金森的数据集中匹配了该31条SNPs的结局数据,采用逆方差加权法、加权中位数和MR-Egger法进行两样本孟德尔随机化分析。结果逆方差加权法结果显示,由遗传决定的血浆中亮氨酸(P=0.037,OR=0.63<1,95%CI:0.4~0.97)和异亮氨酸浓度(P=0.043,OR=0.5<1,95%CI:0.26~0.98)与帕金森有因果关系,并且可以降低帕金森的风险。血浆中缬氨酸浓度(P=0.216,OR=0.79<1,95%CI:0.55~1.15)与帕金森病不存在因果关系。结论血浆中亮氨酸和异亮氨酸可能与PD存在因果关系,且随着血浆中亮氨酸和异亮氨酸浓度升高会降低PD发病风险。
Objective To explore the causal relationship between plasma branched-chain amino acids(leucine,isoleucine and valine)and Parkinson’s disease(PD)using Mendelian randomization.Methods From the UK Biobank,31 samples(P=5×10^(-8))SNPs,and the 31 single nucleotide polymorphism(SNPs)outcome data were matched in Parkinson’s dataset in the Finnish Biobank.Two-sample Mendelian randomization analysis was performed using inverse variance weighting,weighted median and MR-Egger method.Results The results of inverse variance weighting showed that plasma leucine(P=0.037,OR=0.63<1,95%CI:0.4~0.97)and isoleucine concentration(P=0.043,OR=0.5<1,95%CI:0.26~0.98)was causally associated with Parkinson’s disease and reduced the risk of Parkinson’s disease.Plasma valine concentration(P=0.216,OR=0.79<1,95%CI:0.55~1.15)was not associated with Parkinson’s disease.Conclusion Plasma leucine and isoleucine may have a causal relationship with PD,and the risk of PD will be reduced with the increase of plasma leucine and isoleucine concentrations.
作者
张可为
魏元皓
王婷
黄练杰
关冬薇
王一然
于佳颖
潘思佳
张汝楠
冯任南
ZHANG Ke-wei;WEI Yuan-hao;WANG Ting;HUANG Lian-jie;GUAN Dong-wei;WANG Yi-ran;YU Jia-ying;PAN Si-jia;ZHANG Ru-nan;FENG Ren-nan(Department of Mathematics,Heilongjiang Institute of Technology,Harbin 150050,China;Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University,Harbin 150081,China)
出处
《哈尔滨医科大学学报》
CAS
2023年第6期690-695,共6页
Journal of Harbin Medical University
关键词
孟德尔随机化
因果推断
亮氨酸
异亮氨酸
缬氨酸
帕金森病
Mendelian randomization
causal inference
leucine
isoleucine
valine
Parkinson’s disease
