摘要
目的探讨联合清蛋白(ALB)、年龄、氯(Cl)与肌酐(Cr)对特发性膜性肾病(IMN)的诊断价值。方法检测了42例IMN和93例其他肾脏疾病患者的生化指标,收集临床信息并通过AUC筛选出有统计差异的参数,通过二元logistic回归建立辅助诊断模型,并利用ROC曲线评价诊断价值。结果AUC有统计差异的参数(P<0.01)共10项。通过共线性分析,剔除信息冗余参数后,保留ALB、年龄、Cl与Cr,并构建logistic回归模型,ROC曲线分析显示,模型AUC为0.879,最佳截断点处的约登指数为0.5914,敏感性为66.67%,特异性为92.47%,辅助诊断模型(PRE)标准为0.5443,若PRE>0.5443,则判定为IMN患者,反之为其他肾脏疾病患者。结论ALB、年龄、Cl与Cr指标的联合应用对IMN的辅助诊断有一定参考价值。
Objective To explore the diagnostic value of albumins(ALB),age,chlorine(Cl)and creatinine(Cr)in the diagnosis of idiopathic membranous nephropathy(IMN).Methods Biochemical indexes of 42 patients with IMN and 93 patients with other nephropathy were measured,clinical information was collected,parameters with statistical differences were screened out by AUC,diagnostic model was established by binary logistic regression,and diagnostic value was evaluated by ROC curve.Results There were 10 parameters with statistical difference(P<0.01)in AUC.Through collinearity analysis,after eliminating redundant information parameters,ALB,age,Cl and Cr were retained,and then logistic regression model was constructed.ROC curve analysis showed that AUC of the model was 0.879,Youden index J at the best cutoff point was 0.5914,sensitivity was 66.67%,specificity was 92.47%,and the standard of auxiliary diagnosis model(PRE)was 0.5443,meaning if PRE>0.5443,then it was determined as IMN patients,otherwise it was other kidney disease patients.Conclusion The combination of ALB,age,Cl and Cr has certain reference value for the auxiliary diagnosis of IMN.
作者
黎丽芳
陈玉芳
李彦生
LI Lifang;CHEN Yufang;LI Yansheng(Department of Nephropathy and Rheumatism,the Second People′s Hospital of Foshan,Guangdong 528000,China)
出处
《现代医药卫生》
2021年第24期4172-4175,共4页
Journal of Modern Medicine & Health
基金
佛山市卫生和健康局医学科研课题立项项目(20200105)。
