摘要
目的探讨阿魏酸哌嗪联合羟苯磺酸钙治疗糖尿病肾病的疗效及对血清炎症因子和氧化应激因子水平的影响。方法将136例糖尿病肾病患者随机分为对照组、阿魏酸哌嗪组、羟苯磺酸钙组、联合(阿魏酸哌嗪+羟苯磺酸钙)组,各34例。对照组接受常规治疗,阿魏酸哌嗪组、羟苯磺酸钙组、联合组在常规治疗基础上接受相应药物治疗。治疗12周后比较4组患者的疗效、肾功能指标、炎症因子、氧化应激因子水平,记录治疗期间不良反应发生情况。结果治疗后,联合组患者的治疗总有效率高于其他3组患者(均P<0.05)。阿魏酸哌嗪组、羟苯磺酸钙组、联合组患者的血肌酐、血尿素氮、尿微量白蛋白、β2微球蛋白、超敏C反应蛋白、肿瘤坏死因子α、白细胞介素(IL)-1、IL-6、IL-18、活性氧、晚期糖基化终产物、丙二醛水平均低于对照组,超氧化物歧化酶的水平高于对照组患者,联合组患者上述指标改善均优于阿魏酸哌嗪组与羟苯磺酸钙组(均P<0.05)。4组患者治疗期间不良反应发生率差异无统计学意义(P>0.05)。结论与单用阿魏酸哌嗪或羟苯磺酸钙相比,阿魏酸哌嗪与羟苯磺酸钙联合用药可以更好地减轻糖尿病肾病患者的炎症反应及氧化应激,改善肾功能,提高疗效。
Objective To investigate the therapeutic efficacy of piperazine ferulate combined with calcium dobesilate for diabetic nephropathy and its effect on the serum levels of inflammatory factors and oxidative stress factors.Methods A total of 136 patients with diabetic nephropathy were randomly divided into control group,piperazine ferulate group,calcium dobesilate group and combination(piperazine ferulate plus calcium dobesilate)group,with 34 cases in each group.The control group recevied conventional treatment,while on the basis of conventional treatment,the piperazine ferulate,calcium dobesilate and combination groups were treated with corresponding drugs.After 12 weeks of the treatment,efficacy,and the levels of renal function indexes,inflammatory factors,and oxidative stress factors were compared among the four groups,and the incidence of adverse reactions during the treatment was recorded.Results After the treatment,the total effective rate for treatment in the combination group was higher than that in the other three groups(all P<0.05).The piperazine ferulate,calcium dobesilate and combination groups had lower levels of serum creatinine,blood urea nitrogen,microalbuminuria,β2-microglobulin,high-sensitivity C-reactive protein,tumor necrosis factorα,interleukin(IL)-1,IL-6,IL-18,reactive oxygen species,advanced glycation end product,and malondialdehyde,and a higher superoxide dismutase level as compared with the control group;moreover,the combination group was superior to the piperazine ferulate and calcium dobesilate groups in the improvements of the indexes mentioned above(all P<0.05).There was no statistically significant difference in the incidence rate of adverse reactions during treatment among the four groups(P>0.05).Conclusion Compared with the monotherapy of piperazine ferulate or calcium dobesilate,the combined use of piperazine ferulate and calcium dobesilate can preferably reduce inflammatory response and oxidative stress and improve renal function and efficacy in patients with diabetic nephropathy.
作者
黄小丽
曾密帆
许素云
HUANG Xiao-li;ZENG Mi-fan;XU Su-yun(Department of Pharmacy,the Sixth People′s Hospital of Huizhou,Huizhou 516211,China)
出处
《广西医学》
CAS
2021年第20期2415-2420,共6页
Guangxi Medical Journal
关键词
糖尿病肾病
阿魏酸哌嗪
羟苯磺酸钙
炎性因子
氧化应激
Diabetic nephropathy
Piperazine ferulate
Calcium dobesilate
Inflammatory factor
Oxidative stress
