摘要
目的探究卡格列净对糖尿病肾病患者尿蛋白及相关指标的影响,为临床实践提供理论依据。方法选取2019年6月至2020年12月在海宁康华医院住院治疗的糖尿病肾病患者98例为研究对象,采用随机数字表法分为参照组(49例)与研究组(49例)。参照组应用血管紧张素转换酶抑制剂治疗,研究组添加卡格列净治疗,记录两组患者血糖水平、治疗效果、尿蛋白指标、炎性指标、肾功能指标、不良反应、生活质量等情况,并比较两组间有无差异。结果治疗后研究组空腹血糖水平、餐后2 h血糖水平、尿蛋白水平、尿微量蛋白水平、淋巴细胞计数、中性粒细胞计数、尿素氮水平、血肌酐水平、生活质量评分均优于参照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论糖尿病肾病患者应用卡格列净治疗,有效缓解临床症状,控制血糖水平,改善炎性指标与尿蛋白指标,同时还可改善患者的肾功能,提高治疗有效率,可广泛应用于临床。
Objective To explore the effect of Canagliflozin on urinary protein and related indicators in patients with diabetic nephropathy,and to provide theoretical basis for clinical practice.Methods A total of 98 patients with diabetic nephropathy who were hospitalized in Haining Kanghua Hospital from June 2019 to December 2020 were selected as the research objects.The random number table method was used to divide them into a reference group of 49 cases and a study group of 49 cases.The reference group was treated with angiotensin-converting enzyme inhibitors,and the study group was treated with canagliflozin.Record the blood glucose levels,treatment effects,urine protein indicators,inflammatory indicators,renal function indicators,adverse reactions,quality of life,etc.of the two groups of patients,and compare the differences between the two groups.Results After treatment,the study group’s fasting blood glucose level,2 h postprandial blood glucose level,urine protein level,urine microprotein level,lymphocyte count,neutrophil count,urea nitrogen level,blood creatinine level,and quality of life score were better than the reference group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion The application of canagliflozin treatment in patients with diabetic nephropathy can effectively relieve clinical symptoms,control blood sugar levels,improve inflammatory indicators and urine protein indicators,and at the same time improve the patient’s renal function and increase the effective rate of treatment.It can be widely used in clinical practice.
作者
魏垂光
赖小荣
WEI Chuiguang;LAI Xiaolong(Haining Kanghua Hospital,Jiaxing 314400,China)
出处
《中国全科医学》
CAS
北大核心
2021年第S02期143-146,共4页
Chinese General Practice
关键词
糖尿病肾病
卡格列净
血管紧张素转换酶抑制剂
尿蛋白
炎性指标
Diabetic nephropathies
Kaglitazin
Angiotensin converting enzyme inhibitor
Urinary protein
Inflammatory index
