摘要
目的:观察在常规干预措施基础上加用复方益糖康颗粒联合盐酸二甲双胍缓释片治疗气阴两虚型2型糖尿病患者的效果。方法:将纳入的116例气阴两虚型2型糖尿病患者随机分为2组各58例。2组均实施常规干预措施,并内服盐酸二甲双胍缓释片,观察组联合复方益糖康颗粒治疗,2组均连续治疗12周。治疗前后测定糖脂代谢指标[空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)及低密度脂蛋白胆固醇(LDL-C)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽还原酶(GSH-Px)及活性氧类物质(ROS)],评定中医证候评分,比较2组的临床疗效,统计不良反应发生率。结果:治疗12周,观察组总有效率93.10%,对照组总有效率74.14%,2组比较,差异有统计学意义(P<0.05)。2组倦怠乏力、咽干口燥、口渴喜饮、五心烦热、多食易饥评分均低于治疗前(P<0.05),观察组5项中医证候评分均低于对照组(P<0.05)。2组FBG、P2hBG、HbA1c、TC、TG及LDL-C水平均低于治疗前(P<0.05),观察组6项指标值均低于对照组(P<0.05)。2组SOD、GSH-Px水平均高于治疗前,MAD、ROS水平均低于治疗前,差异均有统计学意义(P<0.05);观察组SOD、GSH-Px水平均高于对照组,MAD、ROS水平均低于对照组,差异均有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规干预措施基础上加用复方益糖康颗粒联合盐酸二甲双胍缓释片能调节气阴两虚型2型糖尿病患者的糖脂代谢水平,快速缓解临床症状,提高治疗效果,安全性较高。
Objective:To observe the curative effect of Compound Yitangkang Granules combined with Metformin Hydrochloride Sustained-Release Tablets on patients with type 2 diabetes mellitus with syndrome of dual deficiency of qi and yin based on routine intervention measures.Methods:A total of 116 patients with type 2 diabetes mellitus with dual deficiency qi and yin syndrome were included and randomly divided into two groups,with 58 cases in each group.The two groups were given routine intervention measures and oral administration of Metformin Hydrochloride Sustained-Release Tablets,and the observation group was additionally treated with Compound Yitangkang Granules.The two groups were treated for 12 weeks.Before and after treatment,the indexes of glucose and lipid metabolism,including fasting blood glucose(FBG),2-hour postprandial blood glucose(P2hBG),glycosylated hemoglobin(HbA1c),triglyceride(TG),total cholesterol(TC)and low density lipoprotein-cholesterol(LDL-C),and indexes of oxidative stress,including superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)and reactive oxygen species(ROS)in the two groups were determined,the traditional Chinese medicine(TCM)syndrome scores were evaluated,the clinical effects were compared and the incidence of adverse reactions were counted.Results:After treatment for 12 weeks,the total clinical effective rate was 93.10%in the observation group,higher than that of 74.14%,the difference being significant(P<0.05).The scores of fatigue and lack of strength,dry throat and mouth,dry mouth with desire for drink,feverish sensation in chest and frequent diets and easiness to hunger in the two groups were lower than those before treatment(P<0.05),and the above five TCM syndrome scores in the observation group were lower than those in the control group(P<0.05).The levels of FBG,P2hBG,HbA1c,TC,TG and LDL-C in both groups were lower than those before treatment(P<0.05),and the above six indexes in the observation group were lower than those in the control group(P<0.05).Compare
作者
叶雪卫
金奕
朱光建
YE Xuewei;JIN Yi;ZHU Guangjian(The Seventh Department of Internal Medicine of Wenling Hospital of Traditional Chinese Medicine,Wenling Zhejiang 317500,China)
出处
《新中医》
CAS
2023年第14期77-81,共5页
New Chinese Medicine
关键词
2型糖尿病
气阴两虚证
复方益糖康颗粒
糖脂代谢
氧化应激
Type 2 diabetes mellitus
Syndrome of dual deficiency of qi and yin
Compound Yitangkang Granules
Glucose and lipid metabolism
Oxidative stress
