摘要
感音神经性耳聋主要表现为声波感受障碍引起的听力损失,与耳蜗感觉上皮和螺旋神经元的结构及功能受损密切相关,但具体的病理机制尚不确切。细胞、分子水平的研究证明细胞凋亡、氧化应激损伤、免疫炎症、代谢障碍、基因突变可能参与多种因素引起的内耳细胞损伤或死亡,引起听力损失。本文将围绕上述细胞、分子过程在多种因素引起的感音神经性耳聋内耳细胞损伤和存活中的调控机制进行综述,以帮助研究人员识别关键分子靶点,为干预、治疗感音神经性耳聋新策略提供参考。
Sensorineural hearing loss is mainly manifested as hearing loss caused by sound wave perception disorder,which is closely related to the damage to the structure and function of cochlear sensory epithelium and spiral neurons,but the specific pathological mechanism is not clear now.Studies at the cellular and molecular level have proved that apoptosis,oxidative stress damage,immune inflammation,metabolic disorders,and genetic mutations may be involved in various factors induced inner ear cells damage or death,causing hearing loss.This article will review on the regulatory mechanisms of the above-mentioned molecules and cellular processes in the inner ear cell damage and survival of sensorineural hearing loss,which will help researchers to identify the key molecular targets and provide new theoretical strategies for intervention and treatment of sensorineural hearing loss.
作者
陈海军
孙宗润
郭岩
郝佳琦
高国慧
张潇
王子行
尹海燕
Chen Haijun;Sun Zongrun;Guo Yan;Hao Jiaqi;Gao Guohui;Zhang Xiao;Wang Zixing;Yin Haiyan(School of Basic Medicine,Jining Medical University,Jining 262067,China;Department of Histology and Embryology,Jining Medical University,Jining 262067,China)
出处
《解剖学杂志》
CAS
2021年第6期526-529,共4页
Chinese Journal of Anatomy
基金
国家自然科学基金(82000979)
济宁医学院贺林院士新医学临床转化工作站科研基金(JYHL2019MS13)
济宁医学院教师科研扶持基金(JYFC2019KJ001)
大学生创新实验项目(cx2020125)。
关键词
感音神经性耳聋
细胞凋亡
氧化应激
炎症
分子机制
sensorineural hearing loss
apoptosis
oxidative stress
inflammation
molecular mechanism
