摘要
1,3,5-三嗪烷是一类重要的合成子,可看成是甲醛亚胺的等价物,参与各类含氮杂环骨架的构建.近年来,1,3,5-三嗪烷在含氮杂环化合物的构建中引起了越来越多的关注.基于此,系统综述了1,3,5-三嗪烷作为双原子、三原子以及四原子合成子参与[2+n],[3+n],[4+n]环加成反应构建含氮杂环化合物的反应研究进展,总结了其在环加成、杂环化学以及药物化学中的应用,并展望了基于1,3,5-三嗪烷参与构建含氮杂环骨架及其应用的未来发展趋势.
1,3,5-Triazinanes are an important class of synthons,which could be regarded as the equivalent of formaldehyde imines in constructing various nitrogen-containing heterocyclic skeletons.In recent years,1,3,5-triazinanes have attracted much attention in the construction of nitrogen-containing heterocyclic compounds.Based on this,the participation of 1,3,5-triazinanes as diatomic,triatomic and four-atom synthons in[2+n],[3+n],[4+n]cycloaddition reactions to construct nitrogen-containing heterocyclic compounds is systematically summarized.Its applications in cycloaddition,heterocyclic chemistry and pharmaceutical chemistry are also summarized.Moreover,the development of 1,3,5-triazinanes in the construction of nitrogen-containing heterocyclic skeletons and their future applications are also prospected.
作者
张建涛
周鹏
肖朵朵
刘卫兵
Zhang Jiantao;Zhou Peng;Xiao Duoduo;Liu Weibing(College of Chemistry,Guangdong University of Petrochemical Technology,Maoming,Guangdong 525000)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第11期4154-4166,共13页
Chinese Journal of Organic Chemistry
基金
广东石油化工学院人才引进计划(Nos.2019rc048,2017rc07)
广东石油化工学院创新研究团队(No.519124)
广东省普通高校青年创新基金(No.2018KQNCX167)资助项目.
关键词
1
3
5-三嗪烷
含氮杂环
合成子
环加成反应
药物化学
1,3,5-triazinane
nitrogen-containing heterocycle
synthon
cycloaddition reaction
pharmaceutical chemistry