摘要
生物碱uleine及其衍生物从结构上看属于单萜吲哚生物碱,它们共同的结构特征是吲哚核与碱性氮原子之间只有一个碳相隔,而不像其它单萜吲哚生物碱有两个碳原子.由于其结构特异,天然含量少,因而其合成工作一直吸引着化学工作者.总结uleine生物碱及其衍生物的合成方法,根据构建环的种类不同,把合成方法分为五类.大部分方法都是以吲哚和吡啶衍生物为起始原料进行四环的合成,有几条合成路线简短易行.
Uleine and its derivatives belong to the monoterpenoid indole alkaloids based on their structures.The characteristic of their structures is only one carbon atom which separates the indole nucleus and the basic nitrogen atom,as opposed to the normal two-carbon bridge of tryptamine and most monoterpenoid indole alkaloids.Their natural contents are extremely low,and their synthetic work has attracted generations of chemists.The synthetic methods of uleine and its derivatives are reviewed according to the types of structure building methodology.The indole and pyridine derivatives were used as the starting mate-rial in most tetracyclic synthesis.Several simple and convenient routes are succeeded.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第2期420-430,共11页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.20872118
30070905)
教育部博士点基金(No.20070697012)
陕西省重大科技专项(No.2008ZDKG-67)
陕西省重点实验室基金(Nos.2010JS097
08jk477)资助项目~~
