摘要
吡啶是药物和天然产物的重要骨架,是医药化工的重要的中间体.介绍了过渡金属催化的吡啶在2位、3位或4位发生的烷基化、烯基化和芳基化等C—H键活化反应,还概括了吡啶的官能化在药物和天然产物合成中的应用.
Pyridines are key backbones of drugs and natural products as well as the key intermediates of medicinal engineer- ing. This paper summarizes transition-metal-catalyzed functionalization of pyridines via C--H activation such as alkylation, alkenylation and arylation etc. as well as their utilities in synthesis of drugs and natural products.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第9期1653-1665,共13页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21172166)
浙江省自然科学基金(No.Y4100783)资助项目~~
关键词
吡啶
官能化
烷基化
烯基化
芳基化
pyridines
functionalization
alkylation
alkenylation
arylation
