摘要
目的:观察自拟扶正祛邪方联合西药对溃疡性结肠炎(UC)患者临床疗效与安全性的影响。方法:选择2016年3月~2018年3月青岛市中医医院收治的UC患者120例,随机数字表法分成西药组(n=40)、中药组(n=40)与中西结合组(n=40)。西药组采用柳氮磺吡啶治疗,中药组采用自拟扶正祛邪方治疗,中西结合组采用自拟扶正祛邪方联合柳氮磺吡啶治疗,治疗1个月为1疗程,三组均治疗2个月,观察时间为3个月。比较三组中医疗效,分别在治疗前、后比较三组中医证候评分,检测三组血管活性肠肽(VIP)、生长抑素(SS)、P物质(SP)以及血清白介素-1(IL-1)、白介素-10(IL-10)、白介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)水平,分析患者脑肠肽与机体炎症的变化,并记录三组不良反应发生率。结果:中西结合组(95.00%)总有效率高于西药组(75.00%)、中药组(77.50%)(P<0.05)。三组治疗后主症积分、次症积分及总分均低于治疗前,且中西结合组显著低于西药组、中药组(P<0.05)。三组治疗后VIP、SS、IL-10高于治疗前,且中西结合组高于西药组、中药组,而三组治疗后SP、IL-1、IL-33、TNF-α低于治疗前,且中西结合组低于西药组、中药组(P<0.05)。中西结合组(7.50%)不良反应率与西药组(12.50%)、中药组(5.00%)相较无差异(P>0.05)。结论:与单纯西药或自拟扶正祛邪方治疗相比,采用自拟扶正祛邪方联合西药治疗,能进一步减轻中医症状,改善脑肠肽水平,减轻机体炎症,不良反应率较低,总体疗效良好。
Objective:To explore the effect of Self-made Fuzheng Quxie Decoction combined with western medicine on clinical efficacy and safety for patients with ulcerative colitis(UC).Methods:A total of 120 UC patients admitted to our hospital from March 2016 to March 2017 were included.According to the random number table method,they were divided into a western medicine group(n=40),a traditional Chinese medicine group(n=40)and a combination medicine group(n=40).The western medicine group was treated with Sulfasalazine,the traditional Chinese medicine group was treated with Self-made Fuzheng Quxie Decoction,and the traditional Chinese and Western medicine group was treated with Self-made Fuzheng Quxie Decoction combined with Sulfasalazine.The treatment was 1 month for 1 course,and all three groups were treated with 2 months,the observation period was 3 months.The efficacy of the three groups of Chinese medicine was compared.The scores of the three groups of TCM syndromes were compared before and after treatment,and the three groups of vasoactive intestinal peptide(VIP),somatostatin(SS),substance P(SP)and serum interleukin-1(IL-1),interleukin-10(IL-10),interleukin-33(IL-33),tumor necrosis factor-α(TNF-α)levels.And recorded the incidence of the three groups of adverse reactions.Results:The total effective rate of the combined Chinese and western medicine group(95.00%)was higher than that of the western medicine group(75.00%)and the Chinese medicine group(77.50%)(P<0.05).The scores of the main symptoms,the scores of the secondary symptoms and the total scores of the three groups after treatment were lower than those before the treatment,and the combined Chinese and western medicine group was significantly lower than the western medicine group and the Chinese medicine group(P<0.05).VIP,SS,IL-10 after treatment in the three groups were higher than before treatment,and the combined traditional Chinese and western medicine group was higher than the western medicine group and traditional Chinese medicine group,while the SP,IL-1,I
作者
王亿鹏
刘华一
WANG Yipeng;LIU Huayi(Tianjin University of Traditional Chinese Medicine,Tianjin 301608,China;Department of Hepatobiliary Medicine,Qingdao Hospital of Traditional Chinese Medicine\Qingdao Municipal Haici Hospital,Qingdao Shandong 266033,China;Department of Spleen and Stomach Diseases,the Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine,Tianjin 300131,China)
出处
《四川中医》
2021年第11期119-123,共5页
Journal of Sichuan of Traditional Chinese Medicine
基金
山东省中医药科技发展计划项目(编号:2015-362)。
关键词
溃疡性结肠炎
柳氮磺吡啶
扶正祛邪方
脑肠肽
炎症因子
不良反应
Ulcerative colitis
Sulfasalazine
Fuzheng Quxie Decoction
Brain gut peptide
Inflammatory factors
Adverse reactions
