摘要
目的:探讨米拉贝隆治疗经尿道前列腺电切术(TURP)术后膀胱过度活动症的临床疗效。方法:选取我院2020年2月—2021年1月接受TURP患者90例,随机分为米拉贝隆组(米拉贝隆50 mg, qd)、索利那新组(索利那新5 mg, qd)和对照组(安慰剂治疗),每组30例。记录各组TURP术后前3 d膀胱痉挛次数、痉挛持续时间,尿管拔除后1 d尿频、尿急、夜尿次数,术前及术后1个月最大尿流率(Q_(max))、残余尿(PVR)、膀胱过度活动症评分(OABSS)及生活质量(QOL)评分。结果:米拉贝隆组和索利那新组术后前3 d膀胱痉挛次数、痉挛持续时间均少于对照组(P<0.05);米拉贝隆组术后前3 d膀胱痉挛次数分别为(0.63±0.32)次、(1.67±0.42)次、(1.53±0.43)次,与索利那新组(0.67±0.28)次、(1.73±0.38)次、(1.47±0.45)次比较,差异无统计学意义(P>0.05);米拉贝隆组术后前3 d膀胱痉挛持续时间分别为(0.82±0.54) h、(1.04±0.43) h、(0.78±0.37) h,与索利那新组(0.78±0.48) h、(1.11±0.31) h、(0.81±0.29) h比较,差异无统计学意义(P>0.05)。米拉贝隆组和索利那新组尿管拔除后1 d尿频、尿急、夜尿的次数均少于对照组(P<0.05);米拉贝隆组尿频、尿急、夜尿次数分别为(9.33±2.97)次、(5.87±2.62)次、(1.27±0.29)次,与索利那新组(9.60±3.12)次、(6.17±2.98)次、(1.23±0.32)次比较,差异无统计学意义(P>0.05)。各组间术前Q_(max)和PVR比较,差异均无统计学意义(P>0.05);米拉贝隆组术后1个月Q_(max)和PVR分别为(21.18±6.18) mL/s、(37.38±16.78) mL,与对照组(20.41±6.47) mL/s、(34.32±17.18) mL比较,差异无统计学意义(P>0.05);索利那新组术后1个月Q_(max)和PVR分别为(10.83±6.98) mL/s、(59.76±16.14) mL,与米拉贝隆组及对照组比较,差异均有统计学意义(P<0.05)。各组间术前OABSS和QOL比较,差异均无统计学意义(P>0.05);米拉贝隆组术后1个月OABSS及QOL评分分别为(5.34±1.72)分、(2.32±1.17)分,与索利那新组(5.28±2.14)分、(2.29±1
Objective: To explore the clinical efficacy of mirabegron in the treatment of overactive bladder(OAB) after transurethral resection of the prostate(TURP). Methods: A total of 90 patients who underwent TURP in our hospital from February 2020 to January 2021 were selected and randomly divided into mirabegron group(mirabegron 50 mg, qd), solifenacin group(solifenacin 5 mg, qd), control group, and each group has 30 cases. The postoperative bladder spasm pain frequency and duration of bladder spasm in each group three days after TURP, the frequency of urination, urgency, and nocturia on 1 st day after catheter removal, the maximum urine flow rate(Q_(max)), postvoid residual(PVR), OABSS and QOL score before TURP and one month after TURP were recorded. Results: The number of bladder spasm pain frequency and duration of bladder spasm three days after TURP in the experimental group were less than those in the control group(P<0.05). The number of bladder spasm pain frequency three days after TURP in the mirabegron group were(0.63±0.32) times,(1.67±0.42) times,(1.53±0.43) times, compared with(0.67±0.28) times,(1.73±0.38) times,(1.47±0.45) times in the solifenacin group, the difference was not statistically significant(P>0.05). The duration of bladder spasm three days after TURP in the mirabegron group were(0.82±0.54) h,(1.04±0.43) h,(0.78±0.37) h, compared with the solifenacin group(0.78±0.48) h,(1.11±0.31) h and(0.81±0.29) h, the difference was not statistically significant(P>0.05). The frequency of urination, urgency, and nocturia in the test group on 1 st day after catheter removal were less than those in the control group(P<0.05). The frequency of urination, urgency, and nocturia in the mirabegron group were(9.33±2.97) times,(5.87±2.62) times, and(1.27±0.29) times, compared with the solifenacin group(9.60±3.12) times,(6.17±2.98) times, and(1.23±0.32) times, the difference was not statistically significant(P>0.05). There was no statistically significant difference in the preoperative Q_(max)or PVR among
作者
张乐乐
杨彬
王晋垚
牛向南
冯安昊
孙世伟
岳鹏
张雁钢
ZHANG Lele;YANG Bin;WANG Jinyao;NIU Xiangnan;FENG Anhao;SUN Shiwei;YUE Peng;ZHANG Yangang(Department of Urology,Third Hospital of ShanxiMedicalUniversity,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan,030032,China)
出处
《临床泌尿外科杂志》
CAS
2021年第11期876-880,共5页
Journal of Clinical Urology
关键词
米拉贝隆
索利那新
经尿道前列腺电切术
尿潴留
膀胱过度活动症
mirabegron
solifenacin
transurethral resection of the prostate
urinary retention
overactive bladder
