摘要
目的:研究ADRB2(rs1042713) AA基因型对抗胆碱能药物治疗儿童哮喘的应答相关性。方法:选取昆明市儿童医院2017年6月至2019年6月首次诊断的237例哮喘患儿中的80例ADRB2(rs1042713) AA基因型患儿,随机分为试验组和对照组各40例。试验组患儿予以吸入性糖皮质激素联合抗胆碱能药物治疗,对照组患儿予以吸入性糖皮质激素联合长效β;受体激动剂治疗,分别于治疗前后比较两组患儿儿童哮喘控制测试(C-ACT)评分、肺功能、药物应答情况。结果:治疗后试验组较对照组C-ACT评分、肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、最大呼气流量(PEF)、最大呼气中段流量(MMEF)]改善较大,差异有统计学意义(P<0.05);治疗后试验组39例哮喘患儿中18例有应答,对照组38例哮喘患儿中7例有应答,试验组药物应答率是对照组的3.8倍(P<0.05,OR=3.80,95%CI:1.35~10.68)。结论:ADRB2(rs1042713)基因多态性对药物应答存在差异,且AA基因型对抗胆碱能药物应答较好。
Objective: To study the correlation between the response of ADRB2(rs1042713) AA genotype to anticholinergic drugs in the treatment of children with asthma. Methods: Eighty children with ADRB2(rs1042713) AA genotype among 237 children with asthma first diagnosed in Children’s Hospital of Kunming Medical University from Jun. 2017 to Jun. 2019 were randomly divided into the experimental group and the control group, with 40 children in each group. The experimental group was treated with inhaled glucocorticoid combined with anticholinergic drugs, while the control group received inhaled glucocorticoid combined with long-acting β;agonist. Children’s asthma control test(C-ACT) scores, pulmonary function and drug response were compared between two groups before and after treatment. Results: After treatment, the improvements of C-ACT score and pulmonary function(forced expiratory volume in one second(FEV1), forced vital capacity(FVC), peak expiratory flow(PEF) and maximum midexpiratory flow(MMEF)) in the experimental group were better than those in the control group, with statistically significant differences(P<0.05). After treatment, 18 out of 39 children with asthma in the experimental group responded, and 7 out of 38 children with asthma in the control group responded, the response rate of the experimental group was 3.8 times that of the control group(P<0.05, OR=3.80, 95%CI: from 1.35 to 10.68). Conclusion: ADRB2(rs1042713) gene polymorphism has different responses to drugs, and AA genotype responds better to anticholinergic drugs.
作者
涂彩霞
任丹阳
李云巍
张泉
沈建玲
李振坤
严爱花
宗静
李发双
李惠英
Tu Caixia;Ren Danyang;Li Yunwei;Zhang Quan;Shen Jianling;Li Zhenkun;Yan Aihua;Zong Jing;Li Fashuang;Li Huiying(Children’s Hospital of Kunming Medical University,Yunnan Kunming 650228,China;The Second Affiliated Hospital of Kunming Medical University,Yunnan Kunming 650101,China)
出处
《儿科药学杂志》
CAS
2021年第12期19-22,共4页
Journal of Pediatric Pharmacy
基金
云南省卫生科技计划资助项目,编号2018NS0174
昆明市卫生科技人才培养项目,编号2019后备人选-32。
