摘要
目的优选银花感冒颗粒(无糖型)的最佳制备工艺,并验证中试生产工艺的可行性。方法以金银花中绿原酸转移率和干膏率为评价指标,对加水量、提取时间和提取次数3个因素进行了正交试验考察;以干膏细粉和不同比例糊精、可溶性淀粉和乳糖进行了制备成型试验。结果银花感冒颗粒提取工艺定为:药材加8倍量水提取3次,每次提取1.5 h;将提取液醇沉后浓缩成稠膏,80℃干燥,粉碎成细粉后与糊精、可溶性淀粉和乳糖,以16目尼龙网制粒,75℃烘干,16目筛整粒,即得银花感冒(无糖型)颗粒。结论优化颗粒制备工艺合理、可行,适合工业化生产。
Objective The best preparation process of Yinhua Ganmao Granules(sugar-free)was optimized,and the feasibility of the production process was verified by pre-production test.Methods Taking chlorogenic acid transfer rate and dry extract rate in Flos Lonicerae as evaluation indexes,orthogonal experiments were conducted to investigate the three factors as follows the volume of water,extraction time and extraction times.The preparation and molding tests were carried out with dry extract and dextrin,soluble starch and lactose in different proportions.Results The extraction process of Yinhua Ganmao Granules was as follows:the medicinal materials were extracted 3 times with 8 times of water for 1.5 hours each time.Precipitating the extractive solution with alcohol,concentrating into soft extract,drying at 80℃,pulverizing into fine powder,granulating with dextrin,soluble starch and lactose,granulating with 16 mesh nylon mesh,drying at 75℃,and sift through 16 mesh sieve to obtain Yinhua Ganmao Granules(sugar-free).Conclusion The optimized particle preparation process was reasonable and feasible and suitable for industrial production.
作者
林晓
秦昌金
谢晓燕
王浩骅
王坤
LIN Xiao;QIN Changjin;XIE Xiaoyan;WANG Haohua;WANG Kun(Shandong Institute for Food and Drug Control,Jinan 250101,China;Qingdao West Coast New Area Skin Disease Prevention Station,Qingdao 266400,China;Qixia Dermatology Hospital,Yantai 264000,China;Shandong Xinbao Pharmaceutical Co.,Ltd.,Jinan 250131,China)
出处
《药学研究》
CAS
2021年第11期735-738,共4页
Journal of Pharmaceutical Research
关键词
银花感冒颗粒
成型
制备工艺
Yinhua Ganmao Granules
Preparation
Technology
