摘要
目的:研究清胆颗粒制粒工艺。方法:制备清胆颗粒喷雾干燥浸膏粉,采用干压法、流化法、高速搅拌法制备清胆颗粒;以颗粒粒径分布、流动性及成品率为评价指标,优选清胆颗粒制粒工艺。结果:高速搅拌制粒主要为20～30目的颗粒,流化制粒主要为30～60目颗粒,干压制粒粒径分布广、细粒多;流动性顺序为高速搅拌制粒>流化制粒>干压制粒清胆颗粒;成品率顺序为高速搅拌制粒>流化制粒>干压制粒。结论:采用高速搅拌制粒法制备清胆颗粒,效果优于干压法和流化制粒法,工艺可行,可为进一步研究提供理论基础。
OBJECTIVE： To study the preparation technology of Qingdan granule. METHODS： Qingdan granule were prepared from spray drying powder by dry granulation, fluidized bed granulation, and high speed wet granulation, respectively. And the preparation technology was optimized by taking grain size distribution, grain fluidity, the ratio of finished product as evaluation index. RESULTS： The mesh sizes of Qingdan granule prepared by high speed wet granulation and fluidized bed granulation were ranged between 20 and 30 and between 30 and 60, respectively; and Qingdan granule prepared by dry granulation was characterized by wide grain size distribution and more of fine grains. The grain fluidity and the ratio of finished product of Qingdan granule prepared by the three methods in descending order were high speed wet granulation〉fluidized bed granulation〉 dry granulation. CONCLUSION： High speed wet granulation was proved to be superior to dry granulation and fluidized bed granulation in the preparation of Qingdan granule. The technology of high speed wet granulation is feasible, which has provided theoretical basis for the further study of the preparation of Qingdan granule.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第24期1870-1871,共2页
China Pharmacy
关键词
清胆颗粒
高速搅拌制粒
干压法
流化制粒
Qingdan granule
High speed wet granulation
Dry granulation
Fluidized bed granulation
