摘要
目的研究社区获得性呼吸窘迫综合征毒素(CARDS TX)、肿瘤坏死因子-α(TNF-α)在难治性肺炎支原体肺炎(RMPP)患儿中的表达情况,分析其与患儿血液高凝状态的关系。方法选取2018年6月至2020年6月河南省儿童医院呼吸科收治的90例RMPP患儿作为研究对象(RMPP组),另选择同期于河南省儿童医院呼吸科进行体检的90例健康儿童作为对照组。比较两组纤维蛋白原(Fib)、D-二聚体(D-D)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、CARDS TX、TNF-α水平,分析CARDS TX、TNF-α与RMPP患儿Fib、APTT、PT水平的关系。根据所测CARDS TX相对表达量及TNF-α中位数值,将RMPP患儿分为CARDS TX高水平组和CARDS TX低水平组、TNF-α高水平组和TNF-α低水平组,对比其肺内外并发症发生情况。结果RMPP组Fib、D-D水平高于对照组(P<0.05),APTT短于对照组(P<0.05),PT与对照组比较,差异无统计学意义(P>0.05)。RMPP组CARDS TX、TNF-α水平高于对照组(P<0.05)。相关性分析显示,RMPP患儿CARDS TX、TNF-α水平与Fib、D-D水平呈正相关(P<0.05),与APTT呈负相关(P<0.05),与PT无相关性(P>0.05)。CARDS TX高水平组胸腔积液、肺不张和肝功能异常发生率高于CARDS TX低水平组(P<0.05),肺实变、心肌损害、心包积液和皮疹发生率与CARDS TX低水平组比较,差异无统计学意义(P>0.05)。TNF-α高水平组胸腔积液、肺不张、皮疹发生率高于TNF-α低水平组(P<0.05),肝功能异常、肺实变、心肌损害和心包积液发生率与TNF-α低水平组差异无统计学意义(P>0.05)。结论CARDS TX、TNF-α水平与RMPP患儿血液高凝状态及肺内外并发症有关。
Objective To study the expressions of community-acquired respiratory distress syndrome toxin(CARDS TX)and tumor necrosis factor-α(TNF-α)in children with refractory mycoplasma pneumoniae pneumonia(RMPP),and to analyze their relationship with hypercoagulable state in children.Methods A total of 90 children with RMPP treated in the respiratory department of Henan children’s Hospital from June 2018 to June 2020 were selected as the research objects(RMPP group),and 90 healthy children who underwent physical examination in the respiratory department of Henan children’s Hospital in the same period were selected as the control group.Fibrinogen(Fib),D-Dimer(D-D),activated partial thromboplastin time(APTT),prothrombin time(PT),CARDS TX and TNF-αlevel were compared between the two groups,analyze CARDS TX and TNF-αrelationship with Fib,APTT and PT levels in children with RMPP.According to the measured relative expression of CARDS TX and the median value of TNF-α,children with RMPP were divided into high-level CARDS TX group and low-level CARDS TX group,high-level TNF-αgroup and low-level TNF-αgroup.The occurrence of intrapulmonary and extrapulmonary complications were compared.Results The levels of Fib and D-D in the RMPP group were higher than those in the control group(P<0.05),and APTT was shorter than that in the control group(P<0.05),and there was no statistically significant difference in PT compared to the control group(P>0.05).The levels of CARDS TX and TNF-αin the RMPP group were higher than those in the control group(P<0.05).Correlation analysis showed that CARDS TX and TNF-αin children with RMPP were positively correlated with Fib and D-D(P<0.05),and were negatively correlated with APTT(P<0.05),but were not correlated with PT(P>0.05).The incidence rates of pleural effusion,atelectasis and abnormal liver function in the high-level CARDS TX group were higher than those in the low-level CARDS TX group(P<0.05),and there were no statistically significant differences in the incidence rates of lung consolidat
作者
冯日昇
郭燕军
FENG Risheng;GUO Yanjun(The Second Department of General Medical,Children’s Hospital Affiliated to Zhengzhou University/Henan Children’s Hospital/Zhengzhou Children’s Hospital,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2021年第34期6371-6374,共4页
Henan Medical Research
基金
河南省医学科技攻关计划(联合共建项目)(2018020652)。
