摘要
甲状腺乳头状癌是甲状腺癌中最常见的亚型。虽然通过甲状腺切除术、微波消融术、放射性碘和激素替代治疗甲状腺乳头状癌能达到一定治疗效果,但仍然无法有效地降低其发病率、死亡率和复发率。因此,寻求甲状腺乳头状癌发生发展的分子机制,为甲状腺乳头状癌患者提供有效的早期诊断、精确的治疗以及较好的长期预后显得尤为重要。本文通过总结非编码RNAs及其相关信号通路对甲状腺乳头状癌发生发展的分子调控机制,以期为甲状腺乳头状癌生物标志物的进一步研究提供新思路。
Papillary thyroid carcinoma is one of the most common thyroid cancer subtypes.Although papillary thyroid carcinoma can be treated effectively with excision,microwave ablation,radioactive iodine and hormone replacement therapy,these ways are inefficient in reducing its morbidity,mortality and recurrence rates.Therefore,it is very important to seek the molecular mechanism of the occurrence and development of papillary thyroid carcinoma,to provide effectively early diagnosis,accurate treatment and better long-term prognosis for papillary thyroid carcinoma patients.This paper summarizes the molecular regulatory mechanisms of non-coding RNAs and their related signaling pathways in the occurrence and development of papillary thyroid carcinoma,in order to provide evidence for continued research of biomarkers for papillary thyroid carcinoma.
作者
牛彦强
周祖邦
田利民
安方玉
方媛
张立文
张明华
NIU Yanqiang;ZHOU Zubang;TIAN Limin;AN Fangyu;FANG Yuan;ZHANG Liwen;ZHANG Minghua(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Ultrasound,Gansu Provincial Hospital,Lanzhou 730000,China;Department of Endocrinology,Gansu Provincial Hospital,Lanzhou 730000,China;The Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education,Gansu University of Chinese Medicine,Lanzhou 730000,China)
出处
《肿瘤防治研究》
CAS
CSCD
2021年第11期1030-1034,共5页
Cancer Research on Prevention and Treatment
基金
甘肃省兰州市人才创新创业项目(2019-RC-119)
甘肃省人民医院国家级科研项目培育计划(19SYPYB-26)。
