摘要
抑郁症是一种常见的精神障碍,目前抑郁症的诊断主要依靠患者自述的症状及临床访谈的结果,诊断过程相对主观。作为辅助抑郁症诊断及疗效评估的新技术之一,近红外光谱成像技术(near-infrared spectroscopy,NIRS)近年来受到大量关注。文章整理综述了近年来NIRS在抑郁症的诊断与疗效评估方面的研究进展。结果表明NIRS能反映抑郁症患者脑皮层额颞叶的异常血流动力学活动,尤其是背外侧前额叶及额下回,其氧合血红蛋白浓度的变化辅助诊断抑郁症的准确率较高。目前只有较少的纵向研究使用NIRS比较抑郁症治疗前后脑血流动力学活动的变化,初步证实了NIRS在抑郁症疗效评估应用中的潜力。未来需要更多大样本量的研究来进一步证实NIRS在抑郁症诊断及疗效评估中的具体应用标准。
Depressive disorder is a common mental disorder.At present,the diagnosis of depressive disorder mainly relies on patients'self-reported symptoms and clinical interviews which are relatively subjective.As one of the new technologies assisting diagnosis and therapeutic effect evaluation of depressive disorder,near-infrared spectroscopy(NIRS)has received a lot of attention in recent years.This article reviewed studies of using NIRS in the diagnosis and therapeutic effect evaluation of depressive disorder in the past five years.The review showed that NIRS could reflect abnormal hemodynamic activities of the prefrontal cortex and temporal cortex of patients with depressive disorder,especially the dorsolateral prefrontal cortex and inferior frontal gyrus.Changes of concentration of oxygenated hemoglobin in these areas showed higher accuracy in assisting the diagnosis of depression disorder.Until now,only a few longitudinal studies utilized NIRS to compare changes of cerebral hemodynamic activities at different time points of treatment which preliminarily confirmed the potential of NIRS in the evaluation of therapeutic effects of depressive disorder.In future,more large-scale studies will be needed to further determine the specific application standards for NIRS in the diagnosis and therapeutic effect evaluation of depressive disorder.
作者
顾乔乔
王慧颖
刘聪
董娇
王长虹
Gu Qiaoqiao;Wang Huiying;Liu Cong;Dong Jiao;Wang Changhong(Department of Psychiatry,The Second Affiliated Hospital of Xinxiang Medical University(Henan Mental Hospital),Xinxiang 453002,China;Henan Key Laboratory of Biological Psychiatry,Xinxiang Medical University,Xinxiang 453002,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2021年第9期858-864,共7页
Chinese Journal of Behavioral Medicine and Brain Science
基金
新乡市重大科技专项(ZD2020011)
河南省医学科技攻关计划项目(2018010015,2018020375)
河南省精神心理疾病临床医学研究中心开放课题(2019-zxkfkt-005,2020-zxkfkt-004)。
关键词
抑郁症
近红外光谱成像
辅助诊断
鉴别诊断
疗效评估
Depressive disorder
Near-infrared spectroscopy
Auxiliary diagnosis
Differential diagnosis
Efficacy assessment
