摘要
目的分析给予重度冠心病心肌缺血患者艾司洛尔联合尼可地尔治疗的疗效。方法94例重度冠心病心肌缺血患者,运用随机平衡法分为实验组和常规组,各47例。两组均接受常规治疗,常规组应用盐酸艾司洛尔注射液治疗,实验组应用艾司洛尔联合尼可地尔治疗。比较两组临床疗效、左室功能指标、心电图情况。结果实验组总有效率95.74%高于常规组的80.85%,差异具有统计学意义(P<0.05)。治疗前,两组左室后壁舒张末期厚度、室间隔厚度比较,差异无统计学意义(P>0.05);治疗后,实验组左室后壁舒张末期厚度为(9.18±0.89)mm,室间隔厚度为(9.07±0.67)mm,均小于常规组的(10.67±0.92)、(10.56±0.75)mm,差异具有统计学意义(P<0.05)。治疗前,两组的ST段压低次数、心肌缺血负荷、ST段压持续时间比较差异无统计学意义(P>0.05);治疗后,实验组的ST段压低次数、心肌缺血负荷均小于常规组,ST段压持续时间短于常规组,差异具有统计学意义(P<0.05)。结论在治疗重度冠心病心肌缺血时采取艾司洛尔联合尼可地尔治疗的效果较为理想,可显著改善左室功能,同时还可降低疾病严重性,值得在临床中应用。
Objective To analyze the efficacy of esmolol combined with nicorandil in patients with severe coronary heart disease and myocardial ischemia.Methods A total of 94 patients with severe coronary heart disease and myocardial ischemia were randomly divided into experimental group and conventional group,with 47 cases in each group.Both groups received conventional treatment,the conventional group was also treated with esmolol hydrochloride injection,and the experimental group was treated with esmolol and nicorandil.The clinical efficacy,left ventricular function indexes,and electrocardiogram were compared between the two groups.Results The total effective rate 95.74%of the experimental group was higher than 80.85%of the conventional group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the left ventricular posterior wall end-diastolic thickness and interventricular septum thickness between the two groups(P>0.05).After treatment,the left ventricular posterior wall end-diastolic thickness in the experimental group was(9.18±0.89)mm,and the interventricular septum thickness was(9.07±0.67)mm,both of which were less than(10.67±0.92)and(10.56±0.75)mm of the conventional group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the number of ST-segment depressions,myocardial ischemic load,and ST-segment pressure duration between the two groups(P>0.05).After treatment,the number of ST-segment depression and myocardial ischemic load in the experimental group were less than those in the conventional group,and the ST-segment pressure duration was shorter than that in the conventional group.All the differences were statistically significant(P<0.05).Conclusion Combination of esmolol and nicorandil has ideal effect on patients with severe coronary heart disease and myocardial ischemia,and it can significantly improve left ventricular function,while reducing the severity of the
作者
张晚月
洪书新
ZHANG Wan-yue;HONG Shu-xin(Department of Cardiology,Chaoyang Second Hospital,Chaoyang 122000,China)
出处
《中国现代药物应用》
2021年第20期101-103,共3页
Chinese Journal of Modern Drug Application
关键词
艾司洛尔
尼可地尔
冠心病
心肌缺血
重度
疗效
Esmolol
Nicorandil
Coronary heart disease
Myocardial ischemia
Severe
Efficacy
