摘要
目的探讨重度冠心病心肌缺血加用尼可地尔效果及预后。方法选择重度冠心病心肌缺血100例,均为我院2017年1月至2019年1月收治,随机分组,就单用艾司洛尔治疗(对照组,n=50)与加用尼可地尔治疗(观察组,n=50)总有效率及预后展开比较。结果观察组总有效率经评定为96%,高于对照组82%(P<0.05)。两组治疗前左室功能指标左室后壁舒张末期厚度、室间隔厚度无差异(P>0.05)治疗后均有下降,且观察组下降程度更为显著(P<0.05)。观察组心电图复常时间明显短于对照组,N端脑钠肽前体水平低于对照组(P<0.05)。结论重度冠心病心肌缺血在常规给药基础上,加用尼可地尔治疗,可显著提高治疗效果,改善左室舒张功能,促进体征恢复。
Objective To investigate the effect and prognosis of nicorandil on myocardial ischemia in patients with severe coronary heart disease. Methods 100 cases of severe coronary heart disease with myocardial ischemia were selected and treated in our hospital from January 2017 to January 2019. They were randomly divided into two groups. The total effective rate and prognosis of esmolol alone (control group, n=50) and nicorandil alone (observation group, n=50) were compared. Results The total effective rate of the observation group was 96%, higher than that of the control group 82%(P < 0.05). There was no difference in left ventricular posterior wall end-diastolic thickness and interventricular septum thickness between the two groups before treatment (P > 0.05). After treatment, the left ventricular function index decreased significantly in the observation group (P < 0.05). The electrocardiogram recovery time of the observation group was significantly shorter than that of the control group, and the N-terminal pro-brain natriuretic peptide level was lower than that of the control group (P < 0.05). Conclusion The treatment of severe coronary heart disease with myocardial ischemia combined with nicorandil on the basis of routine administration can significantly improve the therapeutic effect, improve left ventricular diastolic function and promote the recovery of signs.
作者
黄仕武
HUANG Shiwu(Department of Cardiovascular Medicine, Jingmen Rehabilitation Hospital, Jingmen Hubei 448000, China)
出处
《中国继续医学教育》
2019年第25期147-149,共3页
China Continuing Medical Education
关键词
重度
冠心病心肌缺血
尼可地尔
总有效率
左室功能
心电图复常时间
severe
coronary heart disease myocardial ischemia
nicorandil
total effective rate
left ventricular function
electrocardiogram normalization time
