摘要
自身免疫是指免疫系统无法识别自身抗原和组织,通过自身抗体等多种免疫成分,对自身细胞和组织产生免疫应答的一种致病状态。目前的研究表明,长链非编码RNA(Long non-coding RNA,LncRNA)可以通过不同的通路调控人体内细胞增殖分化、信号转导和炎症反应,并在癌症、糖尿病和心血管疾病等多种疾病的发展中发挥关键作用。最近的研究发现1ncRNA在自身免疫性疾病的发病进程中也起到了重要的作用。现对LncRNA在自身免疫病中的研究进展做一综述。
Autoimmunity is a pathogenic state in which autoantibodies and other immune components produce immune responses to their own cells and tissues,because The immune system cannot recognize its own antigens and tissues.Current research shows that Long non-coding RNA(LncRNA) plays a key role in the development of a variety of diseases.It regulates cell proliferation and differentiation,signal transduction and inflammatory response in human body through different pathways,and also plays a key role in cancer,diabetes and cardiovascular diseases.Recent studies have found that LncRNA also plays an important role in the pathogenesis of autoimmune diseases.This article reviews the research progress of Incrna in autoimmune diseases.
作者
王文强
李忠信
刘博男
常富江
丁亚辉
孙萌
谢小倩
WANG Wen-qiang;LI Zhong-xin;LIU Bo-nan;CHANG Fu-jiang;DING Ya-huil;SUN Meng;XIE Xiao-qian(Autobio Diagnostics Co.,Ltd.,Zhengzhou,Henan,450016;College of Pharmacy,Harbin Commercial University,Harbin,Heilongjiang,150000;Department of Urology,Zhengzhou people's Hospital,Zhengzhou,Henan,450000)
出处
《按摩与康复医学》
2021年第20期90-93,共4页
Chinese Manipulation and Rehabilitation Medicine
