摘要
长链非编码RNA(long noncoding RNAs,lncRNAs)是一类长度大于200个核苷酸的非蛋白质编码RNA。绝大多数lncRNA来源于核基因组。但近年研究发现,一些lncRNA是由线粒体基因组编码、转录而成,或定位于线粒体。本文将从线粒体lncRNA的发现与主要种类、线粒体lncRNA的加工和结构,以及它们的功能和应用等几个方面,对线粒体lncRNA进行阐述。线粒体lncRNA可能成为心血管疾病或肿瘤诊断的生物标志物,或在调控线粒体基因表达等方面发挥重要功能。
Long noncoding RNAs（ lncRNAs） are conventionally defined as a class of transcript longer than 200 nucleotides in length lacking protein-coding capability. Most of them are generally produced by nuclear genome. However,some of lncRNAs generated from the mammalian mitochondrial genome or located in mitochondria have been identified. Here,we review the recent findings in mitochondrial lncRNAs,by focusing on their major categories,processing and molecular structure. Mitochondrial lncRNAs may be considered as biomarkers of cardiac disease and cancer. Mitochondrial lncRNAs also have a functional significance on the regulation of mitochondrial gene expression.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2016年第12期1303-1307,共5页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家基础科学人才培养基金(No.J1030831/J0108)资助~~
