摘要
微小RNA(miRNA)是一类非蛋白质编码的小分子RNA,参与调控不同基因的表达,对癌细胞的侵袭和转移有着十分重要的影响。miRNA-181a(miR-181a)参与调控细胞的分化和免疫以及肿瘤的发生发展及预后等。本文就miR-181a的结构和功能,miR-181a在其他恶性肿瘤发病中的作用,miR-181a在口腔鳞状细胞癌发病中的作用等研究进展作一综述,以期为进一步研究miR-181a提供帮助。
MicroRNA is a kind of small noncoding RNA that regulates the expression of different genes and plays an important role in cancer cell invasion, migration and metastasis. Recently, research shows that micro- RNA-181a（miR-181a） regulates processes of cell differentiation, the immune system, tumorigenesis, tumor develop- ment and prognosis. This review introduced the structure of miR-181a and its function in the tumorigenesis and development, especially the research progress on the oral and maxillofacial malignancy, providing the theoretical basis for further study on miR-181a.
出处
《国际口腔医学杂志》
CAS
2013年第1期51-54,共4页
International Journal of Stomatology
基金
国家自然科学基金资助项目(81072228)
广东省科技计划基金资助项目(2012B031800080)
