摘要
目的系统性评价静脉注射硝普钠(SNP)治疗精神分裂症(SZ)的有效性。方法通过PubMed、Web of Science、EMbase、Cochrane Library等英文数据,以及中国生物医学文献数据库、维普、万方和中国知网等中文数据库,检索有关静脉注射硝普钠治疗精神分裂症的随机对照试验,所有数据库检索时限均于2020年11月7日截止。筛选文献、提取数据后,采用Review Manager 5.3软件进行Meta分析。结果最终纳入4个随机对照试验,共134例患者,结果显示,SNP组与对照组PANSS一般精神病理量表评分[MD=0.05(95%CI:-2.63,2.73),P>0.05]、PANSS阳性量表评分[MD=-0.76(95%CI:-1.74,0.23),P>0.05]、PANSS阴性量表评分[MD=-1.77(95%CI:-5.28,1.74),P>0.05]比较均无差异。敏感性分析后,SNP组与对照组PANSS阴性量表评分比较无差异[MD=-0.19(95%CI:-1.62,1.25),P>0.05]。SNP组与对照组BPRS-18量表评分比较有差异[MD=-5.91(95%CI:-11.42,-0.41),P<0.05],但异质性较高(I2=54%)。结论SZ患者对SNP耐受性较好,但与安慰剂比较,笔者无法得出SNP能够改善SZ相关精神症状的结论。
Objectives To undertake a systematic review to evaluate the efficacy of intravenous sodium nitroprusside(SNP)in the treatment of schizophrenia(SZ).Methods PubMed,Web of Science,EMbase,Cochrane Library,WanFang Data,CBM,and CNKI databases were searched up to October 2,2019 to identify randomized controlled trials on the effectiveness of intravenous SNP treatment for SZ.After literature screening and data extraction,we used Review Manager 5.3 to perform the meta-analysis.Results A total of 4 trails with 134 patients were included.The meta-analysis showed that there was no significant difference in the scores of general psychopathology[MD=0.05(95%CI:-2.63,2.73)],positive psychopathology[MD=-0.76(95%CI:-1.74,0.23)]and negative psychopathology[MD=-1.77(95%CI:-5.28,1.74)]as assessed via Positive and Negative Syndrome Scale(PANSS)between the SNP group and the control group(P>0.05).Following the sensitivity analysis,there was also no significant difference in the PANSS negative symptom scores[MD=-0.19(95%CI:-1.62,1.25)].The score of Brief Psychiatric Rating Scale(BPRS)was different between the SNP group and the control group[MD=-5.91(95%CI:-11.42,-0.41)],yet with considerable heterogeneity(I2=54%).Conclusions SNP is relatively well tolerated for the treatment of SZ.However,it is inconclusive whether SNP could improve the mental symptoms associated with SZ.
作者
飞新星
郑晓娇
刘可智
梁雪梅
黄朝华
Xin-xing Fei;Xiao-jiao Zheng;Ke-zhi Liu;Xue-mei Liang;Chao-hua Huang(Department of Psychiatry,The Affiliated Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China)
出处
《中国现代医学杂志》
CAS
北大核心
2021年第20期64-70,共7页
China Journal of Modern Medicine
基金
四川省卫生计生委科研课题(No:16PJ562)。
关键词
精神分裂症
硝普钠
PANSS量表
META分析
sodium nitroprusside(SNP)
schizophrenia(SZ)
Positive and Negative Syndrome Scale(PANSS)
meta-analysis
