摘要
目的:观察温中消疡汤联合常规西药治疗脾胃虚寒型胃溃疡的临床疗效。方法:选取脾胃虚寒型胃溃疡患者120例,按随机数字表法分为对照组和观察组各60例。2组幽门螺杆菌(Hp)阳性患者均先给予标准四联方案进行根除Hp治疗,治疗2周后入组。对照组给予常规西药三联疗法治疗,观察组在对照组基础上给予温中消疡汤治疗。比较2组临床疗效、复发率、中医证候积分、血清核因子-κB (NF-κB)及肿瘤坏死因子-α(TNF-α)水平。结果:观察组总有效率为95.00%,高于对照组83.33%(P<0.05)。治疗后6个月、12个月,观察组复发率均低于对照组(P<0.05)。治疗前,2组各项中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2组各项中医证候积分较治疗前降低,且观察组各项中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组血清TNF-α、NF-κB水平比较,差异无统计学意义(P>0.05)。治疗后,2组血清TNF-α、NF-κB水平较治疗前降低,且观察组血清TNF-α、NF-κB水平低于对照组,差异均有统计学意义(P<0.05)。结论:温中消疡汤联合常规西药治疗脾胃虚寒型胃溃疡患者,可有效提高临床疗效,改善患者症状,提高杀菌、抗炎效果,降低复发率。
Objective:To observe the clinical effect of Wenzhong Xiaoyang tang combined with routine western medicine for gastric ulcer of spleen-stomach deficiency cold type. Methods: A total of 120 cases of patients with gastric ulcer of spleen-stomach deficiency cold type were selected and divided into the control group and the observation group according to the random number table method,60 cases in each group. Patients with helicobacter pylori(Hp) positive in the two groups were given two-week standard quadruple therapy for Hp eradication. The control group was given standard triple therapy of western medicine,and the observation group was additionally treated with Wenzhong Xiaoyang tang based on the treatment of the control group. The clinical effect,the recurrence rate,Chinese medicine syndrome scores,nuclear factor-κB(NF-κB),and tumor necrosis factor-α(TNF-α) were compared between the two groups. Results:The total effective rate was 95.00%in the observation group, higher than that of 83.33% in the control group(P<0.05). After treatment for six and twelve months,the recurrence rate in the observation group was lower than that in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05). After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment, and the scores in the observation group were lower than those in the control group,differences being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of TNF-α and NF-κB in serum between the two groups(P>0.05). After treatment,levels of TNF-α and NF-κB in serum in the two groups were decreased when compared with those before treatment,and the two levels in the observation group were lower than those in the control group,differences being significant(P<0.05). Conclusion:In the treatment of gastric ulcer of spleen-stomach deficiency cold
出处
《新中医》
CAS
2021年第19期98-101,共4页
New Chinese Medicine
关键词
胃溃疡
脾胃虚寒型
温中消疡汤
中医证候积分
复发率
核因子-ΚB
肿瘤坏死因子-α
Gastric ulcer
Spleen-stomach deficiency cold type
Wenzhong Xiaoyang tang
Chinese medicine symptom scores
Recurrence rate
Nuclear factor-κB
Tumor necrosis factor-α
