摘要
目的探讨生长抑素辅助治疗对重症胰腺炎患者胃肠激素的影响。方法将78例重症胰腺炎患者按照随机数字表法分为研究组与对照组,各39例。两组均给予常规治疗,研究组在此基础上给予生长抑素治疗。比较两组临床疗效,比较治疗后两组腹胀腹痛缓解时间、肠道恢复时间、血淀粉酶指数及尿淀粉酶指数。比较治疗前后两组D-乳糖、二胺氧化酶、内毒素水平及乳果糖与甘露醇比值,比较两组血清胆囊收缩素、血管活性肠肽水平。结果研究组治疗总有效率显著高于对照组(P<0.05),腹胀腹痛缓解时间、肠道恢复时间均显著早于对照组(P<0.01),血淀粉酶指数及尿淀粉酶指数均显著低于对照组(P<0.01)。治疗后两组D-乳糖、二胺氧化酶、内毒素水平及乳果糖与甘露醇比值均较治疗前显著降低(P<0.01),研究组显著低于对照组(P<0.01)。治疗后两组胆囊收缩素水平均较治疗前显著升高(P<0.01),血管活性肠肽水平均较治疗前显著降低(P<0.01),研究组较对照组变化更显著(P<0.01)。结论生长抑素辅助治疗重症胰腺炎患者疗效显著,有助于改善患者胃肠激素水平,修复受损肠道黏膜屏障功能。
Objective To observe the effect of somatostatin adjuvant therapy on gastrointestinal hormones in patients with severe pancreatitis.Methods A total of 78 patients with severe pancreatitis were divided into study group and control group according to random number table method,with 39 cases in each group.Both groups were given conventional treatment,and the study group was given somatostatin on the basis of this.The clinical efficacy of the two groups was compared.After treatment,the relief time of abdominal distension and abdominal pain,the recovery time of intestinal tract,blood amylase index and urine amylase index were compared between the two groups.The levels of D-lactose,diamine oxidase(DAO),endotoxin and lactulose/mannitol(L/M value)were compared between the two groups before and after treatment.The serum levels of cholecystokinin(CCK)and vasoactive intestinal peptide(VIP)were compared between the two groups.Results The total effective rate in the study group was significantly higher than that in the control group(P<0.05).The relief time of abdominal distension and abdominal pain and the recovery time of intestinal tract in the study group were significantly earlier than those in the control group(P<0.01),and the blood amylase index and urine amylase index were significantly lower than those in the control group(P<0.01).D-lactate,DAO,endotoxin levels and L/M value of the two groups after treatment were significantly lower than those before treatment(P<0.01),and the study group was significantly lower than the control group(P<0.01).After treatment,the levels of CCK in the two groups were significantly higher than those before treatment(P<0.01),and the levels of VIP were significantly lower than those be fore treatment(P<0.01).The changes in the study group were more significant than those in the control group(P<0.01).Conclusions Adjuvant treatment of somatostatin for severe pancreatitis has a significant effect,which helps to improve the level of gastrointestinal hormones in patients and repair the damaged in
作者
洪巧
朱恵娜
于方远
Hong Qiao;Zhu Huina;Yu Fangyuan(First author’s address Puyang Oilfield General Hospital,Puyang 457000,Henan,China)
出处
《临床心身疾病杂志》
CAS
2021年第5期42-45,共4页
Journal of Clinical Psychosomatic Diseases
关键词
重症胰腺炎
生长抑素
胃肠激素
临床疗效
severe pancreatitis
somatostatin
gastrointestinal hormone
clinical efficacy
